877385-86-9

Basic information

• Product Name: 5-Thiazolecarboxaldehyde, 2-cyclopropyl-
• Synonyms: 5-Thiazolecarboxaldehyde, 2-cyclopropyl-;2-Cyclopropyl-1,3-thiazole-5-carboxaldehyde;2-Cyclopropyl-5-formyl-1,3-thiazole;2-cyclopropylthiazole-5-carbaldehyde;2-cyclopropyl-5-Thiazolecarboxaldehyde
• CAS NO: 877385-86-9
• Molecular Formula: C₇H₇NOS
• Molecular Weight: 153.2
• Mol File: 877385-86-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 278.5±13.0 °C(Predicted)
• Appearance: /
• Density: 1.370±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.66±0.10(Predicted)
• CAS DataBase Reference: 5-Thiazolecarboxaldehyde, 2-cyclopropyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thiazolecarboxaldehyde, 2-cyclopropyl-(877385-86-9)
• EPA Substance Registry System: 5-Thiazolecarboxaldehyde, 2-cyclopropyl-(877385-86-9)

Safety Data

• Hazardous Substances Data: 877385-86-9(Hazardous Substances Data)

Usage

General Description

5-Thiazolecarboxaldehyde, 2-cyclopropyl- is a chemical compound with the molecular formula C7H7NOS. It is a cyclic organic compound containing a thiazole ring and a cyclopropyl group, making it highly reactive and versatile. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also utilized in the production of fragrances and flavors due to its characteristic odor. Additionally, 5-Thiazolecarboxaldehyde, 2-cyclopropyl- is a valuable reagent in various chemical reactions, making it an important building block in organic synthesis. However, it is important to handle this compound with caution, as it can be hazardous if not properly managed and stored.

Upstream product

• 464192-28-7 2-bromo-1,3-thiazole-5-carbaldehyde 
• 411235-57-9 cyclopropylboronic acid 
• 2065-75-0 2-Bromo-malonaldehyde 
• 20295-34-5 cyclopropanecarbothioamide 
• 1159821-56-3 2-cyclopropylthiazole 
• 68-12-2 N,N-dimethyl-formamide 
• 36437-19-1 2-chloromalonaldehyde 

Downstream Products

• 1620545-75-6 3,10-dibromo-6-(2-cyclopropyl-1,3-thiazol-5-yl)-1-fluoro-6H-indolo[1,2-c][1,3]benzoxazine 
• 1613081-64-3 dimethyl((2S,2’S)-((2S,2’S)-2,2’-(5,5’-((S)-6-(2-cyclopropylthiazol-5-yl)-1-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3methyl-1oxobutane-2,1-diyl))dicarbamate 

Relevant articles and documents

THIAZOLE CARBOXAMIDE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS

Provided herein are compounds of Formula (I) and Formula (II) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of tuberculosis.

Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms

We describe the research that led to the discovery of compound 40 (ruzasvir, MK-8408), a pan-genotypic HCV nonstructural protein 5A (NS5A) inhibitor with a "flat" GT1 mutant profile. This NS5A inhibitor contains a unique tetracyclic indole core while maintaining the imidazole-proline-valine Moc motifs of our previous NS5A inhibitors. Compound 40 is currently in early clinical trials and is under evaluation as part of an all-oral DAA regimen for the treatment of chronic HCV infection.

HETEROCYCLE-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES

The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A', R 2 R 3, R 4 and R are as defined herein. The present i