20295-34-5 Usage
Description
Cyclopropanecarbothioamide is used for purification of thiazolo [5, 4-b] pyridine-and thiazolo [5, 4-c] pyridine derivatives from chloronitropyridines and thioamides, or thioureas during the simple-step reaction. It is also a useful chemical during the proteomics study. Recent study has also used it for synthesis of a novel heterocyclic compound, CE-125, which can improve working memory in the radial arm maze and modulate the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat.
Uses
Cyclopropanecarbothioamide is used for purification in single-step preparation of thiazolo [5, 4-b] pyridine-and thiazolo [5, 4-c] pyridine derivatives from chloronitropyridines and thioamides, or thioureas.
References
https://www.alfa.com/en/catalog/H32315/
Hussein, A. M., et al. "A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat." Behavioural Brain Research 332(2017):308-315.
Check Digit Verification of cas no
The CAS Registry Mumber 20295-34-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,2,9 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 20295-34:
(7*2)+(6*0)+(5*2)+(4*9)+(3*5)+(2*3)+(1*4)=85
85 % 10 = 5
So 20295-34-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H7NS/c5-4(6)3-1-2-3/h3H,1-2H2,(H2,5,6)
20295-34-5Relevant articles and documents
Preparation of primary thioamides from nitriles using sodium hydrogen sulfide and diethylamine hydrochloride
Boys, Mark L.,Downs, Victoria L.
, p. 295 - 298 (2006)
Primary thioamides are prepared in moderate to excellent yields by treating nitriles with sodium hydrogen sulfide and diethylamine hydrochloride in an appropriate solvent with mild heating. Copyright Taylor & Francis LLC.
SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS
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Page/Page column 37, (2015/09/22)
The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties. The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.
2-CYCLOPROPYL-THIAZOLE DERIVATIVES
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Page/Page column 12; 22, (2010/09/07)
The invention relates to selected 2-cyclopropyl-thiazole derivatives of the formula (I) wherein B, Y and R1 are as described in the description; to salts and especially pharmaceutically acceptable salts thereof, and to the use of such compounds use as med
