20295-34-5

Usage

Uses

Used in Chemical Synthesis:
Cyclopropanecarbothioamide is used as a purification agent for the single-step preparation of thiazolo[5,4-b]pyridine and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides or thioureas. This application is crucial for obtaining pure and well-defined products in chemical synthesis.
Used in Proteomics Studies:
In the field of proteomics, Cyclopropanecarbothioamide serves as a valuable chemical, aiding in the study of proteins and their interactions within biological systems.
Used in Pharmaceutical Research:
Cyclopropanecarbothioamide has been utilized in the synthesis of CE-125, a novel heterocyclic compound that has shown promise in improving working memory and modulating the dopamine receptor D1R in the frontal cortex of Sprague-Dawley rats. This application highlights its potential in the development of new pharmaceuticals targeting cognitive functions and neurological disorders.

References

https://www.alfa.com/en/catalog/H32315/ Hussein, A. M., et al. "A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat." Behavioural Brain Research 332(2017):308-315.

InChI:InChI=1/C4H7NS/c5-4(6)3-1-2-3/h3H,1-2H2,(H2,5,6)

Upstream product

• 5500-21-0 cyclopropropanecarbonitrile 
• 6228-73-5 Cyclopropancarbamid 

Downstream Products

• 877385-86-9 2-cyclopropylthiazole-5-carbaldehyde 
• 1038508-84-7 methyl 2-cyclopropyl-5-phenyl-1,3-thiazole-4-carboxylate 
• 757155-82-1 4-(chloromethyl)-2-cyclopropylthiazole 
• 1083282-58-9 2-cyclopropyl-5-(3-methyl-phenyl)-thiazole-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Preparation of primary thioamides from nitriles using sodium hydrogen sulfide and diethylamine hydrochloride

Primary thioamides are prepared in moderate to excellent yields by treating nitriles with sodium hydrogen sulfide and diethylamine hydrochloride in an appropriate solvent with mild heating. Copyright Taylor & Francis LLC.

Domino aryne precursor: Efficient construction of 2,4-disubstituted benzothiazoles

An aryne precursor with a potential to perform domino aryne chemistry was proposed and synthesized. The reaction of this reagent with benzothioamide derivatives could afford 2,4-disubstituted benzothiazole with sequential incorporation of C-S, C-N, and C-C bonds on the consecutive three positions of the aryne precursor.

SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS

The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties. The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.

2-AZA-BICYCLO[3.3.0]OCTANE DERIVATIVES

The invention relates to 2-aza-bicyclo[3.3.0]octane derivatives of Formula (I) wherein A, B, and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

2-CYCLOPROPYL-THIAZOLE DERIVATIVES

The invention relates to selected 2-cyclopropyl-thiazole derivatives of the formula (I) wherein B, Y and R1 are as described in the description; to salts and especially pharmaceutically acceptable salts thereof, and to the use of such compounds use as med

MODULATORS OF CXCR7

Compounds having formula (I) or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present inven

PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES

The invention relates to novel phenethylamide derivatives and their heterocyclic analogues of formula (I), wherein A, B, R1, R2 and R3 are as described in the application, and to the use of such compounds, or of pharmaceut

TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

2-AZA-BICYCLO[3.3.0]OCTANE DERIVATIVES

The invention relates to 2-aza-bicyclo[3.3.0]octane derivatives of Formula (I) wherein A, B, and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES

The invention relates to novel 2-aza-bicyclo[2.2.1]heptane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as m