877629-46-4Relevant academic research and scientific papers
Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis
Goodell, John R.,Ougolkov, Andrei V.,Hiasa, Hiroshi,Kaur, Harneet,Remmel, Rory,Billadeau, Daniel D.,Ferguson, David M.
, p. 179 - 182 (2008/09/17)
A series of substituted 9-aminoacridines is evaluated for antiproliferative activity toward pancreatic cancer cells. The results indicate that the compounds inhibit cell proliferation by inducing a G1-S phase arrest. A model is also developed that explain
Identification of compounds with anti-West Nile virus activity
Goodell, John R.,Puig-Basagoiti, Francesc,Forshey, Brett M.,Shi, Pei-Yong,Ferguson, David M.
, p. 2127 - 2137 (2007/10/03)
The lack of antiviral compounds targeting flaviviruses represents a significant problem in the development of strategies for treating West Nile Virus (WNV), Dengue, and Yellow Fever infections. Using WNV high-throughput screening techniques developed in o
Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity
Goodell, John R.,Madhok, Avni A.,Hiasa, Hiroshi,Ferguson, David M.
, p. 5467 - 5480 (2007/10/03)
The discovery of new non-nucleoside antiviral compounds is of significant and growing interest for treating herpes virus infections due to the emergence of nucleoside-resistant strains. Using a whole cell virus-induced cytopathogenic assay, we tested a se
