87905-22-4

Upstream product

• 4461-33-0 benzoyl isocyanate 
• 30216-01-4 2-phenyl-2-oxazolin-4-one 
• 26254-07-9 (1,3-diphenyl-1H-1,2,4-triazol-5-yl)methanol 
• 100-63-0 phenylhydrazine 
• 1426444-51-0 5-(bromomethyl)-1,3-diphenyl-1H-1,2,4-triazole 
• 107428-00-2 5-cyano-4-methylseleno-2-phenyl-1,3-thiazin-6-one 
• 97242-63-2 5-cyano-4-methylthio-2-phenyl-1,3-oxazin-6-one 
• 80532-88-3 5-cyano-4-(methylthio)-2-phenyl-1,3-oxazine-6-thione 

Downstream Products

• 1426444-52-1 2-(1,3-diphenyl-1H-1,2,4-triazol-5-yl)ethanamine 

Relevant academic research and scientific papers

PDE10 MODULATORS

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used in the treatment of CNS disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease.

PDE10 MODULATORS

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.

Heteroatom Rearrangements. S,N, O,N, and N,N Double Rearrangements. X-Ray Molecular Structure of 5-Cyano-6-methylthio-2,3-diphenyl-pyrimidin-4(3H)-one

New heteroatom rearrengements are reported; 'S,N, O,N, and N,N double rearrangements' take place when acrylonitriles, substituted at C-3 by two heteroatom groups (MeS or MeSe, and SH, OH, or NHPh), condense with aromatic carboxylic acids in the presence o

O,N and N,N Double Rearrangement

2-Cyano-3-hydroxy-3-(methylthio)acrylamide and 2-cyano-3-methylthio-3-(phenylamino)acrylamide condense with benzoic acid in the presence of polyphosphoric acid trimethylsilyl ester to give 5-cyano-4-methylthio-2-phenyl-1,3-oxazin-6-one (O,N double rearran

Chemistry of 1,3-Oxazine-6-thiones. Ring Transformation

Two 1,3-oxazine-6-thione derivatives obtained by "S,N-Double Rearrangement" reacted with several nucleophiles to produce 1,3-diazin-6-ones, 6-imino-1,3-oxazines, 1,3,4-triazoles, 1,2,4-oxadiazoles, and 1,3-thiazol-6-ones.Their ring transformations are dis