87918-95-4

Upstream product

• 100-39-0 benzyl bromide 
• 83896-44-0 glycyrrizhin 
• 6738-17-6 O-benzyl-N,N'-dicyclohexylisourea 

Downstream Products

• 87918-96-5 6',6'',30-tribenzyl-18β-glycyrrhizin pentaacetate 
• 87919-12-8 hydroxysuccinimidyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate 
• 87919-08-2 benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate 
• 87919-07-1 benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-ε-aminohexanoate 
• 87919-10-6 N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylic acid 
• 87919-01-5 6',6''-di-tert-butyl-30-benzyl-18β-glycyrrhizin 
• 87918-99-8 30-benzyl-18β-glycyrrhizin 
• 51984-75-9 benzyl (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate 

Relevant academic research and scientific papers

Synthesis of benzyl esters of glycyrrhizic acid in the presence of phase-transfer catalysts

Benzyl esters of glycyrrhizic acid were synthesized using PhCH2Br in DMSO-CH2Cl2-NaOH in the presence of phase-transfer catalysts, such as tetraalkylammonium salts and 2-methyl-2-propanol.

TRANSFORMATIONS OF GLYCYRRHIZIC ACID. X. SYNTHESIS OF NEW ESTERS

The esters of glycyrrhizic acid (trimethyl, tributyl, triallyl, tribenzyl) were synthesized by treating the glycoside in DMSO with an excess of the respective alkyl halide in the presence of potassium hydroxide.The structure of the obtained compounds was

Studies on the Enzyme Immunoassay of Bio-active Constituents Contained in Oriental Medicinal Drugs. II. Enzyme Immunoassay of Glycyrrhizin

In order to develop an enzyme immunoassay of glycyrrhizin (GL), N-(glycyrrhizinyl)-ε-aminohexanoic acid and -trans-4-aminomethylcyclohexanecarboxylic acid were synthesized as haptens from GL via 6',6''-di-tert-butyl GL (VI) as a key intermediate, which was obtained by the selective tert-butylation of GL with O-tert-butyl-N,N'-dicyclohexylisourea or by the hydrogenolysis of 6',6''-di-tert-butyl-30-benzyl GL (V) over palladium carbon.Coupling of the hapten with bovine serum albumin (BSA) (carrier protein) and β-galactosidase (labelled enzyme) was carried out by the N-hydroxysuccinimide ester method.Anti-GL serum was elicited in rabbits by immunization with N-(glycyrrhizinyl)-ε-aminohexanoic acid-BSA conjugate (XIV).Separation of bound and free fractions was perfomed by a double antibody method using a goat antiserum to rabbit IgG. 7-β-D-Galactopyranosyl-4-methylcoumarin was used as the substrate for the fluorometric assay of β-galactosidase activity.A satisfactory standard curve for GL was obtained in the range of 0.2-20 ng/ml.Keywords --- enzyme immunoassay; glycyrrhizin; ε-aminohexanoic acid; trans-4-(aminomethyl)cyclohexanecarboxylic acid; N-hydroxysuccinimide ester method; O-tert-butyl-N,N'-dicyclohexylisourea; O-benzyl-N,N'-dicyclohexylisourea; β-galactosidase; 7-β-D-galactopyranosyloxy-4-methylcoumarin