879220-58-3

Upstream product

• 99113-28-7 (3S,4S)-5-[(tert-butoxycarbonyl)amino]-3-hydroxy-5-phenyl-1-pentene 
• 138760-82-4 (3S,4S)-4-Amino-5-phenyl-pent-1-en-3-ol 
• 879220-55-0 (3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene 
• 879220-83-4 (3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene 
• 879220-56-1 (3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-5-phenylpent-1-en-3-ol 
• 878440-96-1 (3S,4S)-3-[(tert-butyl)dimethylsilyloxy]-4-[N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene 
• 879220-57-2 (5S,6S)-6-benzyl-5,6-dihydro-1-[(2,4-dimethoxy)benzyl]-5-hydroxypyridin-2-one 
• 108-24-7 acetic anhydride 

Downstream Products

• 879220-68-5 (3S,6S)-3,6-dibenzyl-3,6-dihydro-1-(2,4-dimethoxybenzyl)pyridin-2-one 
• 214072-05-6 (3R,6S)-N-[(2,4-Dimethoxyphenyl)methyl]-3,6-dibenzyl-3,6-dihydro-2-pyridone 
• 176217-62-2 (6S)-3,6-dihydro-6-phenylmethyl-1H-pyridin-2-one 
• 879220-63-0 (6S)-6-benzyl-3,6-dihydro-1-[(2,4-dimethoxy)benzyl]pyridin-2-one 

Relevant academic research and scientific papers

Synthesis of (Z)-alkene and (E)-fluoroalkene-containing diketopiperazine mimetics utilizing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations

We have carefully examined the organocopper-mediated reduction-alkylation of γ-acetoxy or γ,γ-difluoro-α,β-unsaturated- δ-lactams for the synthesis of (Z)-alkene- or (E)-fluoroalkene-containing diketopiperazine mimetics. Reduction of acetates 2, 12, 14, a

Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probe structural requirements of the peptide transporter PEPT1

Described is a novel synthetic route for dipeptide isosteres containing (Z)-alkene and (E)-fluoroalkene units as cis-amide bond equivalents via organocopper-mediated reduction of γ-acetoxy- or γ,γ-difluoro- α,β-unsaturated-δ-lactams. The synthesized isost