879220-57-2Relevant academic research and scientific papers
Synthesis of (Z)-alkene and (E)-fluoroalkene-containing diketopiperazine mimetics utilizing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations
Niida, Ayumu,Mizumoto, Makiko,Narumi, Tetsuo,Inokuchi, Eriko,Oishi, Shinya,Ohno, Hiroaki,Otaka, Akira,Kitaura, Kazuo,Fujii, Nobutaka
, p. 4118 - 4129 (2007/10/03)
We have carefully examined the organocopper-mediated reduction-alkylation of γ-acetoxy or γ,γ-difluoro-α,β-unsaturated- δ-lactams for the synthesis of (Z)-alkene- or (E)-fluoroalkene-containing diketopiperazine mimetics. Reduction of acetates 2, 12, 14, a
Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probe structural requirements of the peptide transporter PEPT1
Niida, Ayumu,Tomita, Kenji,Mizumoto, Makiko,Tanigaki, Hiroaki,Terada, Tomohiro,Oishi, Shinya,Otaka, Akira,Inui, Ken-Ichi,Fujii, Nobutaka
, p. 613 - 616 (2007/10/03)
Described is a novel synthetic route for dipeptide isosteres containing (Z)-alkene and (E)-fluoroalkene units as cis-amide bond equivalents via organocopper-mediated reduction of γ-acetoxy- or γ,γ-difluoro- α,β-unsaturated-δ-lactams. The synthesized isost
Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-S N2′ reactions and their use in the preparation of low-molecule CXCR4 antagonists
Niida, Ayumu,Tanigaki, Hiroaki,Inokuchi, Eriko,Sasaki, Yoshikazu,Oishi, Shinya,Ohno, Hiroaki,Tamamura, Hirokazu,Wang, Zixuan,Peiper, Stephen C.,Kitaura, Kazuo,Otaka, Akira,Fujii, Nobutaka
, p. 3942 - 3951 (2007/10/03)
Organocopper-mediated anti-SN2′ reactions of γ-phosphoryloxy-α,β-unsaturated-δ-lactams were used to prepare highly functionalized diketopiperazine mimetics. The substrate phosphates 24, 32, and 47 were prepared from a-amino acid-derived allylic
