87944-07-8

Upstream product

• 100-52-7 benzaldehyde 
• 623-73-4 diazoacetic acid ethyl ester 
• 103-72-0 phenyl isothiocyanate 
• 1985-12-2 4-Bromophenyl isothiocyanate 
• 1544-68-9 4-fluorophenyl isothiocyanate 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 2392-68-9 3-chlorophenyl-isothiocyanate 
• 124-40-3 dimethyl amine 
• 532-55-8 Benzoyl isothiocyanate 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 177328-30-2 ethyl-2-bromo-4-phenyl-1,3-thiazol-5-carboxylate 
• 6972-05-0 1,1-dimethyl-2-thiourea 
• 55919-47-6 ethyl 2-bromo-3-oxo-3-phenylpropionate 

Downstream Products

• 906099-51-2 2-(dimethylamino)-4-phenyl-1,3-thiazole-5-carboxylic acid 

Relevant academic research and scientific papers

A Synthesis of Functionalized Thiazoles and Pyrimidine-4(3 H)-thiones from 1,1,3,3-Tetramethylguanidine, Acetylenic Esters, and Aryl Isothiocyanates

Aryl isothiocyanates react with dialkyl 2-{[bis(dimethylamino)methylene]amino}maleates, generated from 1,1,3,3-tetramethylguanidine and acetylenic esters, to afford 2-(dimethylamino)-1,3-thiazole derivatives, functionalized 2-(dimethylamino)-6-thioxo-1,6-dihydropyrimidines, and ethyl 2-(dimethylamino)-6-[(4-nitrophenyl)im ino]-4-phenyl-6 H -1,3-thiazine-5-carboxylate, in moderate to good yields.

Convenient synthesis of 2,3-dihydro-1,2,4-thiadiazoles, 4,5-dihydro-1,3-thiazoles, and 1,3-thiazoles through a [4+1]-type oxidative ring closure of 1,3-thiaza-1,3-butadienes

1,3-Thiaza-1,3-butadienes bearing an N,N-dimethylamino group at the C-2 position were efficiently converted into 5H-1,2,4-oxathiazoles, 2,3-dihydro-1,2,4-thiadiazoles, 4,5-dihydro-1,3-thiazoles, and 1,3-thiazoles through an oxidative ring closure by treating with mCPBA, chloramine-T, metal carbenoids, or dichlorocarbene, respectively, via the ring closure of in situ generated heterocumulene-type reactive species involving thione S-oxides, thione S-imides, and thiocarbonyl ylides.

One-pot chemoenzymatic multicomponent synthesis of thiazole derivatives

A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards different substrate amines. This trypsin-catalyzed multicomponent conversion method provides a novel strategy to synthesize thiazole derivatives and expands the application of enzymes in organic synthesis.

THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY

The invention provides compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein A, R1, R2 and R3 are as defined in the specification; a process for their preparation; pharmaceutical compositions con

N,N-Disubstituted 2-Aminothiazole-5-carboxylates: Preparation and Rotation of Functional Groups

A series of new alkyl N,N-disubstituted 2-aminothiazole-5-carboxylates was prepared by condensing α-bromo-β-oxo-esters with N,N-disubstituted thioureas.The products exhibit i.r. carbonyl doublets, the higher and lower wavenumber components arising from th