879562-00-2

Upstream product

• 24474-93-9 2-methyl-4H-oxazol-5-one 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 103-72-0 phenyl isothiocyanate 
• 543-24-8 N-acetylglycine 
• 881-90-3 4-benzylidene-2-methyl-2-oxazolin-5-one 
• 538-51-2 benzylidene phenylamine 
• 40913-25-5 4-Benzylidene-2-styryl-Δ²-1,3-oxazolin-5-one 
• 115127-03-2 N-cinnamoylamino glycine 
• 16534-24-0 N-cinnamoylglycine 

Relevant academic research and scientific papers

Synthesis and medicinal properties of 4-benzylidene-1-phenyl-2-(substituted styryl)imidazolin-5-ones

A series of 4-benzylidene-1-phenyl-2-(substituted styryl)imidazolin-5-ones have been synthesized by the interaction of 4-benzylidene-2-methyloxazol-5-one with different Schiff bases, prepared by simple condensation of aniline and various substituted benzaldehydes. The title compounds were evaluated for antiinflammatory activity in carrageenan foot paw edema model and in vitro antioxidant activity. Among the 14 compounds synthesized, dimethyl amino derivative and sterically hindered phenolic derivatives were found to possess good antiinflammatory activity which also exhibited antioxidant properties.

A novel one flask synthesis of 1,2-substituted 5-imidazolones

One flask synthesis of 4-arylmethylene-1-phenyl-2-styryl-2-imidazolin-5- ones was achieved by the phenyl isothiocyanate-mediated condensation of N-acetyl glycine with aromatic aldehydes.

Synthesis of 4-Arylidene--1,2-disubstituted-Δ2-imidazolin-5-ones

Addition of 2-substituted-5-oxo-4,5-dihydro-1,3-oxazoles (5-oxazolones) (3) to imines in benzene leads to the formation of 4-arylidene-Δ2-1,3-oxazolin-5-ones (8) which undergo aminolysis and subsequent cyclisation to the corresponding 4-arylidene-1,2-disubstituted-Δ2-imidazolin-5-ones (10) on heating under reflux in gl. acetic acid.