87974-77-4

Upstream product

• 93267-04-0 N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester 
• 335628-17-6 (4S,5R)-3-tert-butoxycarbonyl-4-butyl-5-methoxy-2-oxazolidinone 
• 75-65-0 tert-butyl alcohol 
• 96789-62-7 (S)-2-Isocyanato-hexanoic acid methyl ester 
• 811-49-4 ethyllithium 
• 76969-87-4 tert-Butyloxycarbonyl-L-α-amino-γ-bromobutyric acid methyl ester 
• 21754-55-2 L-norleucine methyl ester 
• 56926-94-4 methyl (2S)-2-[N-(t-butoxycarbonyl)amino]-3-(4-methylbenzenesulfonyl)-oxypropionate 
• 2417-93-8 propyllithium 
• 76969-87-4 methyl (2S)-4-bromo-2-[(tert-butoxycarbonyl)amino]butanoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3844-54-0 HCl-L-norleucine methyl ester 
• 101650-17-3 (S)-2-amino-4-bromobutyric acid methyl ester 
• 335627-74-2 (4S,5R)-4-butyl-5-methoxy-2-oxazolidinone 

Downstream Products

• 497947-62-3 {(S)-1-[2-Cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pentyl}-carbamic acid tert-butyl ester 
• 116640-17-6 tert-butyl [(1S)-1-(hydroxymethyl)pentyl]carbamate 
• 865537-84-4 2-[(S)-2-((S)-2-Cyclohexyl-1-methyl-ethoxycarbonylamino)-1-hydroxy-hexyl]-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 865537-89-9 {(S)-1-[Hydroxy-(4-trifluoromethyl-thiazol-2-yl)-methyl]-pentyl}-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester 
• 865537-85-5 2-[(S)-2-((S)-2-Cyclohexyl-1-methyl-ethoxycarbonylamino)-1-hydroxy-hexyl]-thiazole-4-carboxylic acid ethyl ester 
• 865537-95-7 2-[(S)-2-(1-Benzyl-3-methyl-butoxycarbonylamino)-1-hydroxy-hexyl]-thiazole-4-carboxylic acid ethyl ester 
• 865537-90-2 2-[(S)-2-(1-Benzyl-2-methyl-propoxycarbonylamino)-1-hydroxy-hexyl]-thiazole-4-carboxylic acid ethyl ester 
• 865537-92-4 2-[(S)-2-(1-Benzyl-propoxycarbonylamino)-1-hydroxy-hexyl]-thiazole-4-carboxylic acid ethyl ester 
• 6404-28-0 Boc-Nle-OH 
• 104062-70-6 (S)-N-Boc-leucinal 

Relevant academic research and scientific papers

A facile synthesis of (S)-gizzerosine, a potent agonist of the histamine H2-receptor

A simple and direct approach for the synthesis of (S)-gizzerosine, an amino acid responsible for the disease, black vomit, and a potent histamine H2-receptor, has been developed in 10 steps and in 31% overall yield from l-aspartic acid. The key steps involved a two-carbon homologation of an l-aspartic acid semi-aldehyde and direct alkylation of unprotected histamine with a 6-hydroxynorleucine derivative.

Design of small molecule ketoamide-based inhibitors of cathepsin K

A novel series of ketoamide-based inhibitors of cathepsin K has been identified. Modifications to P2 and P3 elements were crucial to enhancing inhibitory activity. Although not optimized, a selected inhibitor was effective in attenua

Versatile synthons for optically pure alpha-amino aldehydes and alpha-amino acids: (+)- and (-)-4,5-dialkoxy-2-oxazolidinones.

Both enantiomers of trans-5-benzyloxy-4-methoxy- (BMOx) and trans-4,5-dimethoxy-2-oxazolidinones (DMOx), which are readily accessible from simple 2-oxazolone heterocycles, represent good candidates for a new class of chiral synthons for use in the preparation of optically pure alpha-amino aldehydes and alpha-amino acids, respectively.

LES ORGANOCUPRATES DANS UNE NOUVELLE SYNTHESE D'AMINOACIDES ENANTIOMERIQUEMENT PURS

A new general method of synthesis of optically pure α- amino esters was elaborated during studies on the reaction of organocuprates with tosyl and halogeno derivatives of L-serine and L-homoserine.

ORGANOCUPRATES MEDIATED CARBON-CARBON BOND FORMATION IN γ POSITION OF α-AMINO ESTERS WITHOUT RACEMISATION

A new general method of synthesis of optically pure α-amino esters by action of organocuprates on t-butyloxycarbonyl-L-α-amino-γ-bromobutyric acid methyl ester is described.

LITHIUM DIORGANOCUPRATE REACTIONS WITH L-SERINE DERIVATIVES

The lithium diorganocuprate reactions with L-serine derivatives are studied.Retention of configuration, or at least a high enantiomeric excess (> 80percent) of the formed α-amino esters is observed in all cases.Attempts are made to restrict side-reactions.