87999-87-9

Basic information

• Product Name: 4-N-PROPYLPYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 4-N-PROPYLPYRIDINE-2-CARBOXYLIC ACID;4-N-PROPYLPYRIDINEPICOLINIC ACID;4-propylpicolinic acid
• CAS NO: 87999-87-9
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.19
• Mol File: 87999-87-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 327.5°C at 760 mmHg
• Flash Point: 151.8°C
• Appearance: /
• Density: 1.143g/cm³
• Vapor Pressure: 8.18E-05mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: 4-N-PROPYLPYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-PROPYLPYRIDINE-2-CARBOXYLIC ACID(87999-87-9)
• EPA Substance Registry System: 4-N-PROPYLPYRIDINE-2-CARBOXYLIC ACID(87999-87-9)

Safety Data

• Hazardous Substances Data: 87999-87-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NO2/c1-2-3-7-4-5-10-8(6-7)9(11)12/h4-6H,2-3H2,1H3,(H,11,12)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 1122-81-2 4-n-propylpyridine 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 
• 61702-15-6 4-propylpyridin-2-amine 
• 857221-61-5 2-bromo-4-propylpyridine 
• 124-38-9 carbon dioxide 

Relevant articles and documents

Novel lincomycin derivatives possessing antibacterial activity

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Lincomycin derivatives possessing antibacterial activity

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Synthesis and antimicrobial actvity of clindamycin analogues: Pirlimycin, a potent antibacterial agent

The preparation of a series of analogues of clindamycin is described in which the naturally occurring five-membered cyclic amino acid amide portion of the molecule is replaced by a four-, six-, or seven-membered cyclic amino acid amide. The most interesting compounds is pirlimycin (U-57,930E), in which the (2S-trans)-4n-propylhygramide portion of clindamycin is replaced by (2S-cis)-4-ethylpipecolamide. This structural modification results in significantly favorable changes in toxicity, metabolism, and antibacterial potency. Although the in vitro antibacterial activity of clindamycin and pirlimycin are nearly identical, the latter compounds is 2-20 times more active than clindamycin when administered to mice experimentally infected with strains of Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Bacteroides fragilis, and Plasmodium berghei. Pirlimycin is absorbed in rats and mice and is sequestered within these abscesses. A drug concentration of at least 60 times the required inhibitory concentration is maintained for 6 h following a single subcutaneous dose of 200 mg/kg. Urinary excretion of total bioactivity consists only of intact pirlimycin with no other antibacterially active metabolites being detected. Pirlimycin is tolerated well in rats and mice at the administered levels.