88009-93-2

Upstream product

• 3336-65-0 (α-Aminobenzyliden)propandinitril 
• 18270-61-6 2-cyano-3-chlorocinnamonitrile 
• 98-88-4 benzoyl chloride 
• 158042-64-9 C₁₀H₉N₃S 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 42754-56-3 2-(methoxyphenylmethylene)malononitrile 
• 92119-50-1 3-amino-2-cyano-3-phenylthioacrylamide 

Downstream Products

• 24979-23-5 3,3'-diphenyl-5,5'-triazene-1,3-diyl-bis-isothiazole-4-carbonitrile 
• 25039-62-7 5-nitrosoamino-3-phenyl-isothiazole-4-carbonitrile 
• 19363-60-1 5-chloro-3-phenyl-4-isothiazolecarbonitrile 
• 92119-50-1 3-amino-2-cyano-3-phenylthioacrylamide 
• 158042-65-0 5-amino-3-phenylisothiazole-4-carboxamide 
• 158042-61-6 3-phenylisothiazolo<5,4-d>pyrimidin-4(5H)-one 
• 24979-19-9 5-methylamino-3-phenyl-isothiazole-4-carbonitrile 
• 24979-17-7 5-(methyl-nitroso-amino)-3-phenyl-isothiazole-4-carbonitrile 
• 24979-31-5 3-phenyl-5-(2,4,6-trimethyl-phenylazo)-isothiazole-4-carbonitrile 
• 24979-30-4 5-(2-hydroxy-naphthalen-1-ylazo)-3-phenyl-isothiazole-4-carbonitrile 
• 24979-33-7 5-methoxyazo-3-phenyl-isothiazole-4-carbonitrile 
• 24979-34-8 5-tert-butoxyazo-3-phenyl-isothiazole-4-carbonitrile 
• 24979-27-9 5-hydroxyazo-3-phenyl-isothiazole-4-carbonitrile; ammonium salt 

Relevant academic research and scientific papers

Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation

The synthesis and structure-activity relationship studies of isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors are discussed. The pharmacokinetic profile of 10 and 21 with adequate CNS penetration, required for in vivo Parkinson's disease mod

SYNTHESIS AND FLASH VACUUM PYROLYSIS OF ISOXAZOLO- AND ISOTHIAZOLOPYRIMIDINES

The multi-step synthesis of isothiazolopyrimidines (1c, 1d) and isoxazolopyrimidine (1b) is described.Flash vacuum pyrolysis of 1b leads to phenyliminopropadienone, Ph-N=C=C=C=O, which was identified by Ar matrix infrared spectroscopy.