880152-35-2

Upstream product

• 104155-55-7 6-Methyl-4-(trimethylsiloxy)-2H-pyran-2-on 
• 122135-83-5 ethyl 2-trifluoromethanesulfonyloxycyclohex-1-enecarboxylate 
• 83499-38-1 6-butyl-4-hydroxy-2H-1-pyran-2-one 
• 675-10-5 4-hydroxy-6-methyl-2-pyron 
• 880152-33-0 acetic acid 2-[4-(tert-butyl-diphenyl-silanyloxy)-3-(6-butyl-2-oxo-2H-pyran-4-ylamino)-butyl]-cyclohex-1-enylmethyl ester 
• 880152-31-8 [1-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-hydroxymethyl-cyclohex-1-enyl)-propyl]-carbamic acid tert-butyl ester 
• 880152-28-3 acetic acid 2-[3-amino-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-cyclohex-1-enylmethyl ester 
• 880152-29-4 4-[2-(2-ethoxycarbonyl-cyclohex-1-enyl)-ethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 880152-30-7 2-(3-tert-butoxycarbonylamino-4-hydroxy-butyl)-cyclohex-1-enecarboxylic acid ethyl ester 
• 880152-32-9 4-bromo-6-butyl-2-pyrone 

Downstream Products

• 934296-28-3 C₃₆H₄₇NO₃Si 
• 934296-47-6 3-(tert-butyl-diphenyl-silanyloxymethyl)-5-hexyl-decahydro-pyrrolo[2,1-j]quinoline 
• 880152-44-3 C₃₆H₄₄ClNO₄Si 
• 880152-40-9 C₃₆H₄₇NO₄Si 
• 880152-39-6 C₃₆H₄₅NO₄Si 
• 880152-45-4 C₃₆H₄₇NO₃Si 
• 880152-41-0 3-(tert-butyl-diphenyl-silanyloxymethyl)-5-hexyl-2,3,8,9,10,11-hexahydro-1H,7aH-pyrrolo[2,1-j]quinolin-7-one 
• 880152-43-2 C₃₆H₄₅NO₃Si 
• 880152-36-3 C₃₆H₄₅NO₃Si 

Relevant academic research and scientific papers

Aza-[3 + 3] annulations. Part 6. Total syntheses of putative (-)-lepadiformine and (-)-cylindricine C

Efforts in achieving an enantioselective total synthesis of (-)-cylindricine C along with the syntheses of putative lepadiformine, epi-lepadiformines, (-)-4-deoxo-cylindricine C, and (-?-2-epi-cylindricine C are described here in details. These syntheses feature a stereoselective intramolecular aza-[3 + 3] annulation as a unified strategy, and specifically, the total synthesis of (-)-cylindricine C was accomplished in 22 steps with a 4.5% overall yield from L-serine. In addition, we developed an interesting halohydrin formation for the construction of the C4-ketone of cylindricines.