88039-50-3Relevant academic research and scientific papers
A simple and facile stereoselective synthesis of (Z)- and (E)-allyl halides catalyzed by silica supported sodium hydrogen sulfate: Factors influencing the yields and stereochemistry of allyl halides
Das, Biswanath,Banerjee, Joydeep,Ravindranath, Nasi
, p. 8357 - 8361 (2004)
A simple, mild and efficient stereoselective synthesis of (Z)- and (E)-allyl bromides and iodides has been developed by treatment of the Baylis-Hillman adducts with lithium bromide and iodide, respectively, in methylene chloride catalyzed by silica suppor
Synthesis of 1-benzhydryl piperazine derivatives and evaluation of their ACE inhibition and antimicrobial activities
Santhoshi, Amlipur,Kumar, Singam Naveen,Sujitha, Pombala,Poornachandra, Yedla,Sadhu, Partha Sarathi,Kumar, C. Ganesh,Rao, Vaidya Jayathirtha
, p. 3207 - 3219 (2014/05/06)
This study presents the synthesis of 14 new 1,4-disubstituted piperazine derivatives from allyl bromides of Baylis-Hillman adduct and 4,4-disubstituted benzhydryl piperazines. All the synthesized compounds were further screened for in vitro ACE inhibitor and antimicrobial activities. Among the synthesized piperazine derivatives, compound 12h showed moderate ACE inhibitor activity as compared to the standard, angiotensin-converting enzyme inhibitor (Sigma). The kinetic data (K m, K i and V max values) of enzyme inhibition for compound 12h and ACE inhibitor standard were also determined. Similarly, all compounds were screened against different bacterial strains. Compounds 12a, 12b, 12d, 12h and 12i showed excellent to moderate activity against various tested bacterial strains. Compounds 12b and 12i showed broad spectrum of antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, S. aureus MLS 16, Escherichia coli, Bacillus subtilis and Klebsiella planticola, while compounds 12a, 12d and 12i showed promising activity against P. aeruginosa (MIC value of 8.96 μM), S. aureus (MIC value of 42.2 μM) and S. aureus MLS 16 (MIC value of 81.3 μM), respectively. The remaining compounds showed activity at a concentration of >491 μM.
Mild and practical stereoselective synthesis of (Z)- and (E)-allyl bromides from Baylis-Hillman adducts using Appel agents (PPh3/CBr4): a facile synthesis of semiplenamides C and E
Das, Biswanath,Damodar, Kongara,Bhunia, Nisith,Shashikanth, Boddu
supporting information; experimental part, p. 2072 - 2074 (2009/09/05)
Appel agents (PPh3/CBr4) have been utilized for high-yielding stereoselective synthesis of (Z)- and (E)-allyl bromides from Baylis-Hillman adducts at room temperature. The method has been applied for the synthesis of naturally occurr
A rapid and efficient stereoselective synthesis of (Z)- and (E)-allyl bromides from Baylis-Hillman adducts using bromo(dimethyl)sulfonium bromide
Das, Biswanath,Venkateswarlu, Katta,Krishnaiah, Maddeboina,Holla, Harish,Majhi, Anjoy
, p. 1417 - 1421 (2007/10/03)
Treatment of Baylis-Hillman adducts 1 with bromo(dimethyl)sulfonium bromide, Br(Me2)S+Br-, in MeCN was found to stereoselectively afford (Z)- and (E)-allyl bromides 2. The reaction is rapid at room temperature, high-yieldi
Necic Acid Synthons. Part 2. Regioselectivity in the Reactions of (Z)-2-Bromomethyl-2-alkenoate Esters with Selected Carbon Nucleophiles
Ameer, Farouk,Drewes, Siegfried E.,Emslie, Neville D.,Kaye, Perry T.,Mann, R. Leigh
, p. 2293 - 2295 (2007/10/02)
The preparation of selected (Z)-2-bromomethyl-2-alkenoate esters and their subsequent reaction with acetoacetic ester-derived nucleophiles is described.Both the substrate structure and the solvent system have significant effects on the regioselectivity of these nucleophilic displacements.
