88114-44-7

Upstream product

• 6100-74-9 3-hydroxy-4-methoxyacetophenone 
• 75-26-3 isopropyl bromide 
• 113964-90-2 1-(3-isopropoxy-4-methoxyphenyl)ethanol 
• 75-30-9 2-iodo-propane 
• 34123-66-5 O-isopropylisovanillin 
• 621-59-0 isovanillin 

Downstream Products

• 88114-45-8 3'-isopropoxy-3,4,4'-trimethoxychalcone 
• 52259-64-0 fagaronine 
• 88114-47-0 2-(3,4-dimethoxyphenyl)-4-(3-isopropoxy-4-methoxyphenyl)-4-oxobutyric acid 
• 88114-46-9 2-(3,4-dimethoxyphenyl)-4-(3-isopropoxy-4-methoxyphenyl)-4-oxobutyronitrile 
• 113964-91-3 2-(3,4-dimethoxyphenyl)-6-isopropyloxy-7-methoxy-3,4-dihydronaphthalen-1(2H)-one 
• 113964-89-9 2-(3,4-dimethoxyphenyl)-4-(3'-isopropyloxy-4'-methoxy)phenyl butyric acid 
• 88114-53-8 cis-2-(3,4-dimethylphenyl)-6-isopropoxy-7-methoxy-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine 
• 95118-04-0 6-(4-methoxy-3-isopropoxyphenyl)-3[2H]pyridazinone 
• 6100-74-9 3-hydroxy-4-methoxyacetophenone 
• 1416576-43-6 C₂₇H₂₉NO₅S 
• 1416576-44-7 C₂₄H₂₃NO₅S 
• 1416576-45-8 C₂₅H₂₅NO₅S 
• 1416576-74-3 2-(3-isopropoxy-4-methoxyphenyl)-1H-indole 
• 945612-58-8 2-bromo-1-(3-isopropoxy-4-methoxyphenyl)ethanone 

Relevant academic research and scientific papers

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors

New arylthioindole derivatives having different cyclic substituents at position 2 of the indole were synthesized as anticancer agents. Several compounds inhibited tubulin polymerization at submicromolar concentration and inhibited cell growth at low nanomolar concentrations. Compounds 18 and 57 were superior to the previously synthesized 5. Compound 18 was exceptionally potent as an inhibitor of cell growth: it showed IC50 = 1.0 nM in MCF-7 cells, and it was uniformly active in the whole panel of cancer cells and superior to colchicine and combretastatin A-4. Compounds 18, 20, 55, and 57 were notably more potent than vinorelbine, vinblastine, and paclitaxel in the NCI/ADR-RES and Messa/Dx5 cell lines, which overexpress P-glycoprotein. Compounds 18 and 57 showed initial vascular disrupting effects in a tumor model of liver rhabdomyosarcomas at 15 mg/kg intravenous dosage. Derivative 18 showed water solubility and higher metabolic stability than 5 in human liver microsomes.

NON-STEROIDAL COMPOUNDS

The present invention relates to non-steroidal compounds useful in the treatment of inflammatory conditions and pharmaceutical compositions comprising them. A representative example of these compounds is formula (III).

Studies on the Chemical Constituents of Rutaceous Plants. Part 62. Efficient Synthesis of Fagaronine, a Phenolic Benzophenanthridine Alkaloid with Antileukaemic Activity

Fagarinone (2), an antileukaemic hydroxybenzophenanthridine alkaloid, has been synthesized from the chalcone (4a) according to the synthetic sequence (Schemes 1-4).During the synthesis, the hydroxy group was protected in the form of its isopropoxy deri