6-Fluoroquinazoline-2,4-diol

Base Information

Chemical Name:6-Fluoroquinazoline-2,4-diol
CAS No.:88145-90-8
Molecular Formula:C8H5 F N2 O2
Molecular Weight:180.138
Hs Code.:2933990090
European Community (EC) Number:675-768-9
DSSTox Substance ID:DTXSID10586542
Nikkaji Number:J2.840.226K
Wikidata:Q72466664
Mol file:88145-90-8.mol

Synonyms:88145-90-8;6-fluoroquinazoline-2,4-diol;2,4-dihydroxyl-6-fluoroquinazoline;6-fluoroquinazoline-2,4(1H,3H)-dione;2,4-Dihydroxy-6-fluoroquinazoline;6-fluoro-1H-quinazoline-2,4-dione;6-fluoro-1,2,3,4-tetrahydroquinazoline-2,4-dione;6-fluoro-2,4(1H,3H)-Quinazolinedione;2,4(1H,3H)-Quinazolinedione, 6-fluoro-;SCHEMBL1383605;DTXSID10586542;24-dihydroxyl-6-fluoroquinazoline;QUQJMNPJMVUMNE-UHFFFAOYSA-N;2?4-dihydroxyl-6-fluoroquinazoline;AMY36508;CS-D0544;MFCD09954842;MFCD12024573;AKOS006312893;AKOS015856544;6-Fluoroquinazoline-2 pound not4-diol;6-fluroquinazoline-2,4(1h,3h)-dione;GS-0614;SY032638;2 pound not4-dihydroxyl-6-fluoroquinazoline;DB-077198;EN300-1666755;6-FLUORO-1,3-DIHYDROQUINAZOLINE-2,4-DIONE;J-518759;Z1503739886;2AfAE'A centa' notA inverted exclamation markAfasA'A poundAfAE'A centa' notA inverted exclamation markAfasA'A not4-dihydroxyl-6-fluoroquinazoline

Suppliers and Price of 6-Fluoroquinazoline-2,4-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,4-Dihydroxyl-6-fluoroquinazoline
250mg
$ 120.00

Matrix Scientific
6-Fluoro-1,2,3,4-tetrahydroquinazoline-2,4-dione >95%
1g
$ 232.00

Matrix Scientific
6-Fluoro-1,2,3,4-tetrahydroquinazoline-2,4-dione >95%
500mg
$ 172.00

Matrix Scientific
2,4-Dihydroxyl-6-fluoroquinazoline 98%
1g
$ 248.00

Crysdot
6-Fluoroquinazoline-2,4-diol 98%
5g
$ 238.00

Crysdot
6-Fluoroquinazoline-2,4-diol 98%
10g
$ 416.00

Crysdot
6-Fluoroquinazoline-2,4-diol 98%
25g
$ 842.00

Chemenu
6-Fluoroquinazoline-2,4(1H,3H)-dione 98%
10g
$ 667.00

Chemenu
6-Fluoroquinazoline-2,4(1H,3H)-dione 98%
5g
$ 407.00

Chemenu
6-Fluoroquinazoline-2,4(1H,3H)-dione 98%
1g
$ 138.00

Total 33 raw suppliers

Chemical Property of 6-Fluoroquinazoline-2,4-diol

Chemical Property:

Melting Point:>300 °C
PKA:10.09±0.20(Predicted)
PSA：65.72000
Density:1.434g/cm3
LogP:0.35550
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:180.03350557
Heavy Atom Count:13
Complexity:257

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dihydroxyl-6-fluoroquinazoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1F)C(=O)NC(=O)N2

Technology Process of 6-Fluoroquinazoline-2,4-diol

There total 1 articles about 6-Fluoroquinazoline-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 319-24-4
2-amino-5-fluoro-benzoic acid methyl ester

: 57-13-6
urea

: 88145-90-8
6-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

Guidance literature:: In phenol; at 150 ℃;
DOI:10.1016/j.bmcl.2011.01.117

Reference yield: 86.0%

: 88145-90-8
6-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

: 134517-57-0
2,4-dichloro-6-fluoro-quinazoline

Guidance literature:: With phosphorus pentachloride; trichlorophosphate; for 9h; Reflux;

Reference yield:

: 88145-90-8
6-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

: 113082-27-2
2-chloro-6-fluoroquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate; phosphorus pentachloride / 10 h / 100 °C

2: ammonium hydroxide; zinc / dichloromethane / 4 h / Reflux

With ammonium hydroxide; phosphorus pentachloride; zinc; trichlorophosphate; In dichloromethane;