88154-14-7

Upstream product

• 53008-65-4 methyl 2,3,4-tri-O-benzyl-D-glucopyranoside 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1385808-90-1 3-[6-O-(2-azido)acetyl-2,3,4-tri-O-benzyl-α-D-glucopyranosyl]prop-1-ene 
• 1385808-92-3 3-{2,3,4-tri-O-benzyl-6-O-{4-[(5-dimethylaminonaphthalene-1-sulfonylamino)methyl]-1H-1,2,3-triazol-1-yl}acetyl-α-D-glucopyranosyl}prop-1-ene 
• 53008-65-4 methyl 2,3,4-tri-O-benzyl-D-glucopyranoside 

Relevant academic research and scientific papers

A new method testing the orthogonality of different protecting groups

A new test was elaborated to identify a new set of orthogonal protecting groups. With the developed method eight different protecting groups were tested under various deprotection conditions and the complex reaction mixtures were analysed by HPLC. The dev

Synthesis of triazole-linked fluorescent saccharides and glycosyl amino esters

Synthesis of fluorescent carbohydrates and glycopeptides has been emerging as an attractive research field because of various biological roles of carbohydrates and glycoproteins. Fluorescent glycosides and C-glycosides were synthesized by copper(I)-catalyzed Huisgen reaction between 6-O-(2-azidoacetyl) glycopyranosides and alkyne-functionalized fluorophores. For the fluorescent disaccharides as well as glycosyl amino acids derivatives, glycosylation of azido-functionalized thioglycosides, followed by click reaction with corresponding fluorophores is preferred than the inversed procedure (click reaction before the glycosylation). Fluorophores like dansyl, NBD, or rhodamine have been successfully introduced on the sugar ring. All the newly synthesized fluorescent glycosides and glycoconjugates showed similar photophysical properties to the native fluorophores, with a higher quantum yield for the dansyl derivatives. Georg Thieme Verlag Stuttgart · New York.