881673-82-1

Basic information

• Product Name: 1H-Pyrrole-3-carboxaldehyde, 5-bromo-1-(phenylsulfonyl)-
• CAS NO: 881673-82-1
• Molecular Formula: C11H8BrNO3S
• Molecular Weight: 314.159
• Mol File: 881673-82-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-carboxaldehyde, 5-bromo-1-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxaldehyde, 5-bromo-1-(phenylsulfonyl)-(881673-82-1)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxaldehyde, 5-bromo-1-(phenylsulfonyl)-(881673-82-1)

Safety Data

• Hazardous Substances Data: 881673-82-1(Hazardous Substances Data)

Usage

Molecular Structure

1H-Pyrrole-3-carboxaldehyde, 5-bromo-1-(phenylsulfonyl)is a chemical compound that consists of a pyrrole ring with a carboxaldehyde and a bromine atom, as well as a phenylsulfonyl group attached to the bromine atom.

Usage

This compound is often used in organic synthesis and pharmaceutical research due to its potential biological and pharmacological activities.

Applications

1H-Pyrrole-3-carboxaldehyde, 5-bromo-1-(phenylsulfonyl)can be utilized in the production of various pharmaceutical intermediates and can serve as a valuable building block in the development of new drugs and therapeutic agents.

Importance

This compound is a versatile and important compound with a wide range of potential applications in the field of chemistry and medicine.

Upstream product

• 881673-81-0 [5-bromo-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methanol 
• 7126-39-8 pyrrole-3-carboxaldehyde 
• 98-09-9 benzenesulfonyl chloride 
• 16420-39-6 methyl 5-bromo-1H-pyrrole-3-carboxylate 
• 881673-80-9 methyl 5-bromo-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate 
• 2703-17-5 methyl 1H-pyrrole-3-carboxylate 
• 881676-32-0 5-bromo-1H-pyrrole-3-carboxaldehyde 
• 114615-82-6 tetrapropylammonium perruthennate 
• 70187-32-5 4-methylmorpholine 4-oxide monohydrate 

Downstream Products

• 881673-84-3 tert-butyl {[5-bromo-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-methyl}methylcarbamate 
• 881673-86-5 tert-butyl methyl{[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}carbamate 
• 881678-78-0 N-methyl-1-[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-methanamine hydrochloride 
• 881673-83-2 1-[5-bromo-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine 
• 1055306-36-9 5-(2-chloropyridin-3-yl)-1-[(3-fluorophenyl)sulfonyl]-1H-pyrrole-3-carbaldehyde 
• 1055306-26-7 1-[(2-fluorophenyl)sulfonyl]-5-(2-fluoropyridin-3-yl)-1H-pyrrole-3-carbaldehyde 
• 1055306-37-0 3-{1-[(3-fluorophenyl)sulfonyl]-4-formyl-1H-pyrrol-2-yl}pyridine-2-carbonitrile 
• 1055307-11-3 3-{[2-(2-chloropyridin-3-yl)-4-formyl-1H-pyrrol-1-yl]sulfonyl}benzonitrile 
• 1055306-28-9 5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde 
• 1055306-31-4 4-chloro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrole-3-carbaldehyde 
• 1055304-71-6 1-{1-[(2-fluorophenyl)sulfonyl]-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl}-N-methylmethanamine fumarate 
• 1055304-87-4 3-{1-[(3-fluorophenyl)sulfonyl]-4-[(methylamino)methyl]-1H-pyrrol-2-yl}pyridine-2-carbonitrile fumarate 
• 1055305-46-8 3-({2-(2-chloropyridin-3-yl)-4-[(methylamino)methyl]-1H-pyrrol-1-yl}sulfonyl)benzonitrile fumarate 
• 1055304-75-0 1-(5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)-N-methylmethanamine fumarate 

Relevant articles and documents

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action

With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative 1b as a lead compound. As part of

Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers

To discover a gastric antisecretory agent more potent than existing proton pump inhibitors, novel pyrrole derivatives were synthesized, and their H +,K+-ATPase inhibitory activities and inhibitory action on histamine-stimulated gastric acid secretion in rats were evaluated. Among the compounds synthesized, compound 17a exhibited selective and potent H +,K+-ATPase inhibitory activity through reversible and K+-competitive ionic binding; furthermore, compound 17c exhibited potent inhibitory action on histamine-stimulated gastric acid secretion in rats and Heidenhain pouch dogs.

PROTON PUMP INHIBITORS

A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.