881677-11-8

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)is used as an intermediate in the synthesis of various pharmaceutical compounds for the treatment of acid-related diseases. Its unique structure allows for the development of novel drugs with improved efficacy and reduced side effects.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)serves as a valuable building block for the design and synthesis of new drug candidates. Its presence in the molecular structure can impart specific biological activities, making it a promising candidate for the development of targeted therapies.
Used in Impurity Profiling:
As an impurity of Vonaprazan (V767010), a novel potassium-competitive acid blocker, 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)is important for impurity profiling and quality control in the pharmaceutical industry. Understanding and controlling the presence of this impurity ensures the safety and efficacy of the final drug product.

Upstream product

• 881674-56-2 5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde 
• 42899-76-3 pyridine-3-sulfonyl chloride hydrochloride 
• 1240948-72-4 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 
• 312307-38-3 2-[2-(2-fluorophenyl)-2-oxoethyl]propanedinitrile 
• 1240948-77-9 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 
• 1240948-81-5 S-{3-cyano-5-(2-fluorophenyl)-1H-pyrrol-2-yl}benzenecarbothioate 
• 1240948-83-7 2,2'-disulfanediylbis[5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile] 
• 16133-25-8 Pyridine-3-sulfonyl chloride 
• 64-18-6 formic acid 
• 1807642-39-2 5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile 
• 1993-03-9 o-fluorophenylboronic acid 
• 636-73-7 3-pyridinesulfonic acid 
• 445-27-2 2'-Fluoroacetophenone 
• 655-15-2 2-bromo-2'-fluoroacetophenone 

Downstream Products

• 2098974-13-9 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt 
• 1883595-39-8 C₁₇H₁₄FN₃O₃S 
• 2098974-13-9 (x)C₄H₄O₄*C₁₇H₁₆FN₃O₂S 
• 881681-00-1 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine 
• 928324-99-6 2-bromo-5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 

Relevant academic research and scientific papers

Identification, characterization, synthesis of major metabolites biotransformed from vonoprazan fumarate

A first synthetic research concerning four observed metabolites and their deuterium-labeled analogues of reflux esophagitis drug vonoprazan fumarate is reported. Among which the synthetic methods of three metabolites M ? I, M-III, M-IV-Sul, and four stable isotop labeled analogues M-I-d4, M-II-d4, M-III-d4, M-IV-Sul-d4 have not yet been reported before. The structures of these compounds were elucidated on the basis of MS and NMR spectroscopy.

Preparation method of vonoprazan intermediate

The invention provides a preparation method of a vonoprazan intermediate. Specifically, the vonoprazan intermediate is obtained through a bromination reaction, a sulfonylation reaction, a Vilsmeier reaction and a Suzuki reaction. According to the preparation method, dangerous hydrogenation reaction and low-temperature reaction are avoided, and the reaction has the advantages of mild conditions, easiness in operation, cheap raw materials, low production cost and high total yield.

Preparation method of tenosynol fumarate

The invention discloses a preparation method of fumarate administered by a synthetic digestive system. In particular, the invention relates to a method for large-scale preparation of tenoteno fumarate; the adopted starting materials are easy to obtain; th

Preparation method of high-purity vonoprazan fumarate

The invention discloses a preparation method of high-purity vonoprazan fumarate. The preparation method comprises the steps of 1, preparing 5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl) pyrrole-3-formaldehyde; 2, dissolving the 5-(2-fluorophenyl)-1-(pyridine

3-pyridinesulfonyl-1-N-heteropyrrole derivatives capable of treating peptic ulcer as well as preparation method and application thereof

The invention discloses 3-pyridinesulfonyl-1-N-heteropyrrole derivatives capable of treating peptic ulcer as well as a preparation method and application of the derivative, and particularly provides compounds as shown in a formula I, or pharmaceutically a

Vonoprazan purification method

The invention discloses a purification method of vonoprazan. The method comprises the following steps: preparing a refined solvent from a monohydric alcohol, formamide and water according to a certainratio; and purifying a vonoprazan crude product under t

Vonoprazan fumarate preparation method

The invention provides a vonoprazan fumarate preparation method, which comprises: reducing 5-(2-fluorophenyl)-1-(pyridine-3-ylsulfonyl)-1H-pyrrole-3-formaldehyde with a reducing agent, adding oxalic acid, carrying out a reaction to prepare a crude vonopra

Preparation and purification method of 5-(2-fluorophenyl)-1-(pyridine-3-ylsulfonyl)-1H-pyrrole-3-formaldehyde

The invention provides a preparation and purification method of a key intermediate, 5-(2-fluorophenyl)-1-(pyridine-3-ylsulfonyl)-1H-pyrrole-3-formaldehyde compound (I), for preparing a chemical drug fluorine prazan for treating gastric ulcer, duodenal ulc

An Efficient, Scalable and Eco-friendly Synthesis of 4,5-substituted Pyrrole-3-Carbonitriles by Intramolecular Annulation on Pd/C and HZSM-5

An efficient and eco-friendly protocol for the synthesis of diverse 4,5-substituted 1H-pyrrole-3-carbonitriles has been developed using commercially available HZSM-5 and Pd/C as recyclable heterogeneous catalysts with more excellent yields (up to 98 %) than traditional liquids acids, and successfully applied in the practical synthesis of vonoprazan. The conspicuous features of this protocol are higher product yield, easy work-up, eco-friendly and reusability of catalysts.

Preparation method of low-impurity Vonoprazan fumarate

The invention provides a preparation method of low-impurity Vonoprazan fumarate. A method for removing impurities A-E during preparation of Vonoprazan comprises the steps: preparing Vonoprazan hydrobromide from Vonorazan, and removing the impurities A-E which are difficult to remove by using a recrystallization purifying method, wherein the method for removing the impurities A-E during preparationof Vonoprazan has good selectivity to the impurities A-E. The preparation method of low-impurity Vonoprazan fumarate comprises the steps: performing a reaction on 5-(2-fluorophenyl)-1-(pyridyl-3-ylsulfonyl)-1H-pyrrole-3-formaldehyde and methylamine or a salt of methylamine, then performing reduction so as to obtain Vonoprazan, then preparing Vonoprazan hydrobromide, then performing salt dissociation so as to obtain Vonoprazan free alkali, preparing Vonoprazan fumarate with a purity of 99.7% or above, and then performing recrystallization refining so as to obtain Vonoprazan fumarate with a purity of 99.9% or above. The invention provides an impurity D, a preparation method of the impurity D and application of the impurity D as an impurity reference substance in Vonoprazan fumarate.