881677-11-8

Basic information

• Product Name: 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-
• Synonyms: 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-;5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrole-3-carboxaldehyde;5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-Pyrrole-3-carboxaldehyde;5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldenhyde;Vonoprazan Impurity 19;TAK-438( Vonoprazan fumarate) intermediate 4;(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine
• CAS NO: 881677-11-8
• Molecular Formula: C₁₆H₁₁FN₂O₃S
• Molecular Weight: 330.3335432
• EINECS: -0
• Mol File: 881677-11-8.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 563.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.34±0.11(Predicted)
• CAS DataBase Reference: 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-(881677-11-8)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-(881677-11-8)

Safety Data

• Hazardous Substances Data: 881677-11-8(Hazardous Substances Data)

Usage

Uses

3-Des-N-methylmethanamine Vonoprazan-3-carbaldehyde is an impurity of Vonaprazan (V767010) a novel potassium-competitive acid blocker for the treatment of acid-related diseases.

Upstream product

• 881674-01-7 ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate 
• 881674-06-2 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 881674-58-4 (5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol 
• 881673-98-9 ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate 
• 655-15-2 2-bromo-2'-fluoroacetophenone 
• 1993-03-9 o-fluorophenylboronic acid 
• 64-18-6 formic acid 
• 1807642-39-2 5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile 
• 16133-25-8 Pyridine-3-sulfonyl chloride 
• 881674-56-2 5-(2-fluorophenyl)-1H-pyrrole-3-carboxaldehyde 
• 636-73-7 3-pyridinesulfonic acid 
• 445-27-2 2'-Fluoroacetophenone 
• 1240949-27-2 4-(2-fluorophenyl)-2-(iminomethyl)-4-oxobutanenitrile 
• 1240948-83-7 2,2'-disulfanediylbis[5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile] 

Downstream Products

• 2098974-13-9 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt 
• 881681-00-1 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine 
• 1883595-39-8 C₁₇H₁₄FN₃O₃S 
• 2098974-13-9 (x)C₄H₄O₄*C₁₇H₁₆FN₃O₂S 
• 928324-99-6 2-bromo-5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 

Relevant articles and documents

Identification, characterization, synthesis of major metabolites biotransformed from vonoprazan fumarate

A first synthetic research concerning four observed metabolites and their deuterium-labeled analogues of reflux esophagitis drug vonoprazan fumarate is reported. Among which the synthetic methods of three metabolites M ? I, M-III, M-IV-Sul, and four stable isotop labeled analogues M-I-d4, M-II-d4, M-III-d4, M-IV-Sul-d4 have not yet been reported before. The structures of these compounds were elucidated on the basis of MS and NMR spectroscopy.

Preparation method of tenosynol fumarate

The invention discloses a preparation method of fumarate administered by a synthetic digestive system. In particular, the invention relates to a method for large-scale preparation of tenoteno fumarate; the adopted starting materials are easy to obtain; th

3-pyridinesulfonyl-1-N-heteropyrrole derivatives capable of treating peptic ulcer as well as preparation method and application thereof

The invention discloses 3-pyridinesulfonyl-1-N-heteropyrrole derivatives capable of treating peptic ulcer as well as a preparation method and application of the derivative, and particularly provides compounds as shown in a formula I, or pharmaceutically a