88229-32-7

Basic information

• Product Name: Benzamide, 4-chloro-N-(diphenylmethyl)-
• Synonyms: Benzamide, 4-chloro-N-(diphenylmethyl)-
• CAS NO: 88229-32-7
• Molecular Formula: C20H16ClNO
• Molecular Weight: 321.806
• Mol File: 88229-32-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzamide, 4-chloro-N-(diphenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-chloro-N-(diphenylmethyl)-(88229-32-7)
• EPA Substance Registry System: Benzamide, 4-chloro-N-(diphenylmethyl)-(88229-32-7)

Safety Data

• Hazardous Substances Data: 88229-32-7(Hazardous Substances Data)

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 91-01-0 1,1-Diphenylmethanol 
• 1612225-94-1 N-(tert-butylperoxy(phenyl)methyl)-4-chlorobenzamide 
• 100-58-3 phenylmagnesium bromide 
• 7461-34-9 N-benzyl-p-chlorobenzamide 
• 91-00-9 Benzhydrylamine 
• 74-11-3 para-chlorobenzoic acid 
• 101-81-5 Diphenylmethane 
• 132401-91-3 3-(4-chlorophenyl)-1,4,2-dioxazol-5-one 
• 1613-88-3 4-chloro-N-hydroxybenzamide 
• 619-56-7 4-chlorobenzamide 
• 104-88-1 4-chlorobenzaldehyde 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 40462-76-8 N-[(4-chlorophenyl)methylene]-α-phenylbenzenemethanamine 

Relevant articles and documents

Method for synthesizing amide compound by taking nitrile and diaryl methane as raw materials

The invention discloses a method for synthesizing an amide compound by taking nitrile and diaryl methane as raw materials, the method comprises the following steps: taking diaryl methane as a reaction raw material, nitrile as a raw material and a solvent, 2, 3-dichloro-5, 6-dinitrile group-1, 4-benzoquinone (DDQ) and tert-butyl nitrite (TBN) as catalysts, acid as an auxiliary agent and oxygen as an oxidizing agent, reacting under the conditions of normal temperature, normal pressure and blue light irradiation, and after the reaction is finished, carrying out separation treatment to obtain the amide compound. According to the method, the problem of metal residues in the product can be solved, oxygen is used as a terminal oxidizing agent, the method is environmentally friendly, and energy can be saved.

Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Iridium and Chiral Thiourea Sequential Catalysis

The combination of transition-metal catalysis and organocatalysis increasingly offers chemists opportunities to realize diverse unprecedented chemical transformations. By combining iridium with chiral thiourea catalysis, direct enantioselective reductive cyanation and phosphonylation of secondary amides have been accomplished for the first time for the synthesis of enantioenriched chiral α-aminonitriles and α-aminophosphonates. The protocol is highly efficient and enantioselective, providing a novel route to the synthesis of optically active α-functionalized amines from the simple, readily available feedstocks. In addition, the reactions are scalable and the thiourea catalyst can be recycled and reused.

Air-stable Bis(pentamethylcyclopentadienyl) Zirconium Perfluorooctanesulfonate as an Efficient and Recyclable Catalyst for the Synthesis of N-substituted Amides

Bis(pentamethylcyclopentadienyl) zirconium perfluorooctanesulfonate is an air-stable and water-tolerant Lewis acid. This complex exhibited good thermal stability and high solubility in polar organic solvents. The compound showed relatively strong acidity, with an acid strength of 0.8Ho≤3.3, and high catalytic efficiency for the synthesis of N-substituted amides via the reaction of carboxylic acids with amines, the Ritter reaction of nitriles with alcohols, and the amination of alcohols with amides. Moreover, the complex had good reusability. This catalytic system affords a simple and efficient way to synthesize N-substituted amides.