883035-83-4Relevant academic research and scientific papers
An in-based 3D metal-organic framework as heterogeneous Lewis acid catalyst for multi-component Strecker reactions
Chai, Juan,Zhang, Ping,Xu, Jianing,Qi, Hui,Sun, Jing,Jing, Shubo,Chen, Xiaodong,Fan, Yong,Wang, Li
, p. 165 - 171 (2018)
A novel three-dimensional metal-organic framework (MOF) {[In3(NIPH)3 (HNIPH)(OH)2]·4H2O}n (1) (H2NIPH = 5-nitroisophthalic acid) with one-dimensional channels was synthesized and structurally characterized. Importantly, it demonstrates excellent catalytic activity for the Strecker reactions of two or three components under mild conditions. Moreover, the catalytic recycling of 1 as a representative example was explored. It can be easily separated and reused for no less than five runs with more than 80% conversion yield in catalytic ability.
Strecker reactions with hexacyanoferrates as non-toxic cyanide sources
Grundke, Caroline,Opatz, Till
supporting information, p. 2362 - 2366 (2019/05/17)
The Strecker reaction is the most widely applied three-component reaction. Although highly useful for the preparation of α-amino nitriles, α-amino acids, hydantoins and numerous related compounds, the need for the application of toxic sources of HCN limits its application in both academic and industrial settings. Here, we present a facile protocol for Strecker reactions using a mixture of potassium ferri- and ferrocyanides as a non-toxic substitute.
Synthesis of α-aminonitriles under mild catalytic, metal-free conditions
Nammalwar, Baskar,Fortenberry, Chelsea,Bunce, Richard A.
supporting information, p. 379 - 381 (2014/01/06)
α-Aminonitriles have been synthesized by a Strecker synthesis from aldehydes and ketones under mild catalytic, metal-free conditions. Aromatic aldehydes (1 equiv) were reacted with aromatic and 1 or 2 aliphatic amines (1 equiv) in EtOH containing 3 mol %
