88378-35-2

Usage

InChI:InChI=1/C23H30O5/c1-14(25)28-12-21(27)20-6-5-18-17-4-3-15-11-16(26)7-10-23(15,13-24)19(17)8-9-22(18,20)2/h11,13,17-20H,3-10,12H2,1-2H3/t17-,18-,19-,20+,22-,23+/m0/s1

Upstream product

• 2723-07-1 5-Bromo-6β-hydroxy-20-oxo-5α-pregnan-3β-yl acetate 
• 2685-64-5 5-bromo-6β,19-oxido-3β-hydroxy-5α-androstan-17-one 3-acetate 
• 104494-66-8 19-t-butyldimethylsilyloxy-3-(N-pyrrolidinyl)-pregna-3,5-dien-20-one 
• 104494-69-1 3β-t-butyldimethylsilyloxy-19-(2-tetrahydropyranyloxy)-androst-5-en-17-one 
• 104494-76-0 Acetic acid 2-[(3S,8S,9S,10S,13S,14S)-3-hydroxy-13-methyl-10-(tetrahydro-pyran-2-yloxymethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-2-methoxy-ethyl ester 
• 104494-67-9 19-t-butyldimethylsilyloxydeoxycorticosterone 21-acetate 
• 104494-77-1 Acetic acid 2-methoxy-2-[(8S,9S,10S,13S,14S)-13-methyl-3-oxo-10-(tetrahydro-pyran-2-yloxymethyl)-1,2,3,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-ethyl ester 
• 104494-74-8 2-[(3S,8S,9S,10S,13S,14S)-3-(tert-Butyl-dimethyl-silanyloxy)-13-methyl-10-(tetrahydro-pyran-2-yloxymethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-2-methoxy-ethanol 
• 104494-70-4 methyl 3β-t-butyldimethylsilyloxy-19-(2-tetrahidropyranyloxy)-20-methoxypregna-5,17(20)-dien-21-oate 
• 104494-72-6 t-butyl 3β-t-butyldimethylsilyloxy-19-(2-tetrahydropyranyloxy)-20-methoxypregna-5,17(20)-dien-21-oate 
• 104494-65-7 19-t-butyldimethylsilyloxyprogesterone 
• 104494-64-6 1-[(3S,8S,9S,10S,13S,14S,17S)-10-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone 
• 31751-06-1 (3S,8R,9S,10S,13S,14S)-3-Hydroxy-13-methyl-10-(tetrahydro-pyran-2-yloxymethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-17-one 
• 2857-42-3 3β-acetoxy-19-hydroxyandrost-5-en-17-one 

Downstream Products

• 75220-37-0 19-oxo-deoxycorticosterone 
• 4682-70-6 19-Nordeoxycorticosterone 

Relevant academic research and scientific papers

New Syntheses of 19,21-Dihydropregn-4-ene-3,20-dione, 21-Hydroxy-19-norpregn-4-ene-3,20-dione, and 11β,19,21-trihydroxypregn-4-ene-3,20-dione

19,21-Dihydroxypregn-4-ene-3,20-dione has been synthesized from 3β-acetoxypregn-5-en-20-one via the "hypoiodite reaction" , and Henbest acetoxylation at C-21; oxidation of the intermediate 21-monoacetate to 19-oxo derivative and alkaline cleavage gave 21-hydroxy-19-norpregn-4-ene-3,20-dione.A similar synthesis of 11β,19,21-trihydroxypregn-4-ene-3,20-dione from 3β-acetoxypregn-5-ene-11,20-dione proceeded through intermediates with the 11β-hydroxy function protected as its acetate.Unusual features mainly of conformational origin were observed in the presence of the 11β-acetoxy substituent; some were helpful to the synthesis, while others led to undesirable side reactions.