884-33-3

Basic information

• Product Name: DL-BENZYLSUCCINIC ACID
• Synonyms: Benzenebutanoic acid, beta-carboxy-;AKOS BC-1260;ALPHA-BENZYLSUCCINIC ACID;2-BENZYLSUCCINIC ACID;BENZYL BUTANEDIOIC ACID;DL-BENZYLSUCCINIC ACID;(DL)-2-Benzylsuccinic Acid;à-benzylsuccinic acid
• CAS NO: 884-33-3
• Molecular Formula: C11H12O4
• Molecular Weight: 208.21
• EINECS: -0
• Product Categories: Pharmaceutical Intermediates;Pharmaceutical material and intermeidates;B;Bioactive Small Molecules;Building Blocks;C11 to C12;Carbonyl Compounds;Carboxylic Acids;Cell Biology;Chemical Synthesis;Organic Building Blocks
• Mol File: 884-33-3.mol
• Article Data: 38

Chemical Properties

• Melting Point: 161-163°C
• Boiling Point: 331.4 °C at 760 mmHg
• Flash Point: 168.4 °C
• Appearance: /
• Density: 1.29 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: 3.97±0.10(Predicted)
• BRN: 1966188
• CAS DataBase Reference: DL-BENZYLSUCCINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: DL-BENZYLSUCCINIC ACID(884-33-3)
• EPA Substance Registry System: DL-BENZYLSUCCINIC ACID(884-33-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 884-33-3(Hazardous Substances Data)

Usage

Uses

An effective inhibitor of carboxypeptidase A.

Definition

ChEBI: A dicarboxylic acid consisting of succinic acid carrying a 2-benzyl substituent.

InChI:InChI=1S/C11H12O4/c12-10(13)7-9(11(14)15)6-8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,12,13)(H,14,15)

Upstream product

• 5653-88-3 trans-phenylitaconic acid 
• 213681-40-4 (R)-2-benzylsuccinic acid 
• 100-52-7 benzaldehyde 
• 125702-14-9 (E)-3-(methoxycarbonyl)-4-phenylbut-3-enoic acid 
• 1039497-60-3 (R)-(-)-3-nitromethyl-4-phenylbutanoic acid 
• 21654-18-2 1,4-diethyl 2-benzylsuccinate 
• 35262-43-2 dimethyl 2-benzylsuccinate 
• 501-52-0 3-Phenylpropionic acid 
• 287719-12-4 (R)-4-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-3-benzyl-4-oxo-butyric acid tert-butyl ester 
• 65756-82-3 Z-methyl 4-(phenyl)-3-methoxycarbonylbut-3-enoate 
• 123191-44-6 N,N'-fumaroyldi<(2R)-bornane-10,2-sultam> 
• 6921-34-2 benzylmagnesium chloride 
• 65756-81-2 (Z)-2-benzylidenesuccinic acid 
• 122225-33-6 (2R)-3-tert-Butyloxycarbonyl-2-phenylmethylpropionic Acid 

Downstream Products

• 102543-79-3 3-benzyl-1-dodecyl-pyrrolidine-2,5-dione 
• 122037-64-3 benzyl-succinyl chloride 
• 1648953-38-1 (R)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid 
• 865538-96-1 (S)-3-benzyldihydrofuran-2,5-dione 
• 1220913-25-6 (S)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid 
• 1651204-34-0 (2S)-2-benzyl-4-[(3aS,7aS)-octahydro-2H-isoindole-2-yl]-4-oxobutanoic acid 
• 213681-40-4 (R)-2-benzylsuccinic acid 
• 145375-43-5 mitiglinide 

Relevant articles and documents

Photoinduced Hydrocarboxylation via Thiol-Catalyzed Delivery of Formate across Activated Alkenes

Herein we disclose a new photochemical process to prepare carboxylic acids from formate salts and alkenes. This redox-neutral hydrocarboxylation proceeds in high yields across diverse functionalized alkene substrates with excellent regioselectivity. This operationally simple procedure can be readily scaled in batch at low photocatalyst loading (0.01% photocatalyst). Furthermore, this new reaction can leverage commercially available formate carbon isotologues to enable the direct synthesis of isotopically labeled carboxylic acids. Mechanistic studies support the working model involving a thiol-catalyzed radical chain process wherein the atoms from formate are delivered across the alkene substrate via CO2?- as a key reactive intermediate.

Preparation method of mitiglinide calcium

The invention relates to a preparation method of mitiglinide calcium, which includes steps of step 1, synthesis of benzal butanedioic acid; step 2, synthesis of benzylsuccinic acid; step 3, synthesisof (S)-benzylsuccinic acid (R)-alpha- phenylethylamine; step 4, synthesis of (S)-benzylsuccinic acid; step 5, synthesis of 2S-dihydro-isoindole indolebutyric acid; step 6, synthesis of crude product of mitiglinide calcium; step 7, refining of mitiglinide calcium.

Triflic Acid Mediated Cyclization of Unsymmetrical N -Phenethyl- and N -(3-Indolylethyl)succinimides: Regio- and Diastereoselective Synthesis of Substituted Pyrroloisoquinolinones and Indolizino-indolones

The regio and diastereoselective synthesis of 1 or 2 alkyl-substituted pyrroloisoquinolinones and indolizinoindolones by triflic acid mediated cyclization via an electrophilic activation of unsymmetrical succinimide carbonyl groups followed by the reducti