88412-94-6Relevant academic research and scientific papers
Potential Antitumor Agents. 52. Carbamate Analogues of Amsacrine with in Vivo Activity against Multidrug-Resistant P388 Leukemia
Rewcastle, Gordon W.,Baguley, Bruce C.,Atwell, Graham J.,Denny, William A.
, p. 1576 - 1581 (2007/10/02)
Study of a series of aniline-substituted 9-anilinoacridines related to the antileukemic drug amsacrine showed that a 1'-carbamate group provided increased activity against the multidrug-resistant P388/ADR leukemia subline in vivo.Since activity against su
Potential Antitumor Agents. 41. Analogues of Amsacrine with Electron-Donor Substituents in the Anilino Ring
Atwell, Graham J.,Rewcastle, Gordon W.,Denny, William A.,Cain, Bruce F.,Baguley, Bruce C.
, p. 367 - 372 (2007/10/02)
The preparation and antitumor activity of a series of 3'-alkylamino and 3'-dialkylamino analogues of amsacrine are reported.The results support previous work suggesting that the presence of electron-donating groups in the 3'-position of the anilino ring s
