884495-34-5 Usage
Uses
Used in Pharmaceutical Industry:
3-Fluoro-6-formyl-2-picoline is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of novel drug molecules. Its unique structure allows for the creation of compounds with specific therapeutic properties, enhancing the effectiveness of medications and contributing to advancements in medical treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Fluoro-6-formyl-2-picoline is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can lead to improved performance and selectivity, resulting in more effective and environmentally friendly agricultural solutions.
Used in Medicinal Chemistry Research:
3-Fluoro-6-formyl-2-picoline plays a significant role in medicinal chemistry research, where it is employed as a building block for the design and synthesis of new bioactive molecules. Its presence in these molecules can modulate their biological activity, making it a valuable tool for the discovery of potential therapeutic agents.
Used in Material Science:
In the field of material science, 3-Fluoro-6-formyl-2-picoline is used in the development of new materials with specific properties. Its incorporation into these materials can influence their physical and chemical characteristics, leading to the creation of innovative materials with applications in various industries.
Overall, 3-Fluoro-6-formyl-2-picoline's diverse applications across different industries highlight its importance as a chemical intermediate, making it a crucial component in the advancement of various scientific and technological fields.
Check Digit Verification of cas no
The CAS Registry Mumber 884495-34-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,4,4,9 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 884495-34:
(8*8)+(7*8)+(6*4)+(5*4)+(4*9)+(3*5)+(2*3)+(1*4)=225
225 % 10 = 5
So 884495-34-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H6FNO/c1-5-7(8)3-2-6(4-10)9-5/h2-4H,1H3
884495-34-5Relevant academic research and scientific papers
Palladium-Catalyzed Reductive Carbonylation of (Hetero) Aryl Halides and Triflates Using Cobalt Carbonyl as CO Source
Dogga, Bhushanarao,Joseph, Jayan T.,Kumar, C. S. Ananda
supporting information, p. 309 - 313 (2020/12/23)
An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co2(CO)8 and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.
WDR5 INHIBITORS AND MODULATORS
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Paragraph 0660, (2020/04/24)
Described are imino-azacycle-benzamide compounds compounds that inhibit WDR5 and associated protein-protein interactions, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and c
Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-β type i receptor kinase
Krishnaiah, Maddeboina,Jin, Cheng Hua,Sheen, Yhun Yhong,Kim, Dae-Kee
, p. 5228 - 5231 (2015/11/09)
To further optimize a clinical candidate 5 (EW-7197), a series of 5-(3-, 4-, or 5-fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles 19a-l have been synthesized and evaluated for their TGF-β type I receptor kinase (ALK5) and p38α MAP kinase inhibitory activity in an enzyme assay. The 5-(5-fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles 19h-l displayed the similar level of potency to that of 5 against both ALK5 (IC50 = 7.68-13.70 nM) and p38α MAP kinase (IC50 = 1240-3370 nM). Among them, 19j inhibited ALK5 with IC50 value of 7.68 nM in a kinase assay and displayed 82% inhibition at 100 nM in a luciferase reporter assay.
