88485-94-3

Usage

Uses

Used in Chemical Research and Synthesis:
(naphthalen-1-ylamino)(phenyl)acetonitrile is utilized as a building block in the creation of more complex molecules, contributing to the advancement of chemical research and synthesis. Its unique structure allows for the development of novel compounds with various applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (naphthalen-1-ylamino)(phenyl)acetonitrile is of interest due to the diverse biological activities associated with nitrile-containing compounds. Its potential use in drug development and design could lead to the creation of new therapeutic agents for various medical conditions.
Used in Application Industry:
(naphthalen-1-ylamino)(phenyl)acetonitrile is used as [application type] for [application reason]. (Please provide specific application type and reason for this industry if available.)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 134-32-7 1-amino-naphthalene 
• 108-88-3 toluene 
• 100-52-7 benzaldehyde 
• 890-51-7 N-benzylidenenaphthalen-1-amine 
• 151-50-8 potassium cyanide 
• 532-28-5 (RS)-mandelonitrile 

Relevant academic research and scientific papers

A unique combination of KI/ZnFe2O4 as a catalyst for oxidative Strecker reaction

α-Aminonitriles as key intermediates for the preparation of α-amino acid derivatives, amides, diamines, peptides, proteins and heterocycles were synthesized through methylarene oxidation in the Strecker reaction using a unique combination of KI/ZnFe2O4 as the best catalyst and aqueous tert-butyl hydroperoxide as oxidant. A wide range of amines and methylarenes were converted to the corresponding products. Operational simplicity, short reaction time and recyclability of the catalyst are advantages of this protocol.

Magnetic Fe3O4-BF3: Highly efficient Lewis acid catalyst for the synthesis of α-aminonitriles

Fe3O4 magnetic nanoparticle-supported BF3 was prepared as a new magnetically separable Lewis acid catalyst and successfully used for the one-pot synthesis of α-aminonitriles. A broad range of substrates including the aromatic and heteroaromatic aldehydes, cyclic ketones (cyclopentanone, cyclohexanone and cycloheptanone), aryl-alkyl ketones, diaryl ketones and tetralones, isatin derivatives and acenaphthenequinone were condensed with amines (aliphatic and aromatic) and trimethylsilyl cyanide. All reactions were completed in short times and products were obtained in good to excellent yields. The catalyst could be recycled and reused several times without any loss of efficiency. Finally, α-aminonitrile containing adenine was successfully synthesized.

One-pot three-component synthesis of α-aminonitriles using potassium hexacyanoferrate(II) as an eco-friendly cyanide source

An efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via one-pot three-component condensation of carbonyl compounds, amines, and potassium hexacyanoferrate(II) in the presence of benzoyl chloride as a promoter. This protocol has the features of use of eco-friendly cyanide source, high yield, and simple work-up procedure.

Indium(III) iodide-mediated Strecker reaction in water: an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component condensation

A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.