88511-48-2 Usage
Description
2-Pyrimidinecarboxamide (6CI,7CI,9CI), also known as pyrimidine-2-carboxamide or cytosine, is a pyrimidine derivative with the molecular formula C5H4N4O. It is a heterocyclic compound featuring a ring structure with two nitrogen atoms. Cytosine is a nucleobase found in DNA and RNA, playing a crucial role in the genetic code and the synthesis of nucleic acids. Its unique chemical properties have also led to its exploration for potential therapeutic applications, such as an anti-cancer agent and in the treatment of various other diseases.
Uses
Used in Pharmaceutical Industry:
2-Pyrimidinecarboxamide (6CI,7CI,9CI) is used as a therapeutic agent for its potential anti-cancer properties. It has been studied for its ability to target and inhibit the growth of cancer cells, making it a promising candidate for cancer treatment.
Used in Genetic Research:
As a nucleobase found in DNA and RNA, 2-Pyrimidinecarboxamide (6CI,7CI,9CI) is used in genetic research to understand the fundamental mechanisms of genetic information storage and transmission. Its role in the genetic code and nucleic acid synthesis is essential for advancing our knowledge of genetics and molecular biology.
Used in Drug Development:
2-Pyrimidinecarboxamide (6CI,7CI,9CI) is utilized in drug development for its potential applications in treating various diseases beyond cancer. Its unique chemical structure and interactions with other molecules make it a valuable compound for the design and development of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 88511-48-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,5,1 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 88511-48:
(7*8)+(6*8)+(5*5)+(4*1)+(3*1)+(2*4)+(1*8)=152
152 % 10 = 2
So 88511-48-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H5N3O/c6-4(9)5-7-2-1-3-8-5/h1-3H,(H2,6,9)
88511-48-2Relevant articles and documents
IRAK DEGRADERS AND USES THEREOF
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Paragraph 00920; 003244-003245, (2021/01/23)
The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.
Nitrile Hydration Reaction Using Copper Iodide/Cesium Carbonate/DBU in Nitromethane-Water
Kuwabara, Jun,Sawada, Yoshiharu,Yoshimatsu, Mitsuhiro
supporting information, p. 2061 - 2065 (2018/09/14)
The catalytic nitrile hydration (amide formation) in a copper iodide/cesium carbonate/1,8-diazabicyclo[5.4.0]undec-7-ene/nitromethane-water system is described. The protocol is robust and reliable; it can be applied to a broad range of substrates with high chemoselectivity.
Nickel-Catalyzed Cross-Electrophile Coupling with Organic Reductants in Non-Amide Solvents
Anka-Lufford, Lukiana L.,Huihui, Kierra M. M.,Gower, Nicholas J.,Ackerman, Laura K. G.,Weix, Daniel J.
, p. 11564 - 11567 (2016/08/05)
Cross-electrophile coupling of aryl halides with alkyl halides has thus far been primarily conducted with stoichiometric metallic reductants in amide solvents. This report demonstrates that the use of tetrakis(dimethylamino)ethylene (TDAE) as an organic reductant enables the use of non-amide solvents, such as acetonitrile or propylene oxide, for the coupling of benzyl chlorides and alkyl iodides with aryl halides. Furthermore, these conditions work for several electron-poor heterocycles that are easily reduced by manganese. Finally, we demonstrate that TDAE addition can be used as a control element to ‘hold’ a reaction without diminishing yield or catalyst activity.
