45695-56-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyrimidinecarboximidamide (9CI) is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-Pyrimidinecarboximidamide (9CI) is used as a precursor in the production of agrochemicals, specifically for its herbicidal and insecticidal properties, which can help in the development of effective crop protection agents.
Used in Antitumor and Antiviral Applications:
2-Pyrimidinecarboximidamide (9CI) is studied for its potential use as an antitumor agent, indicating its capacity to target and inhibit the growth of tumor cells, and as an antiviral agent, suggesting its ability to interfere with viral replication and infection processes.
Used in Chemical Compounds Synthesis:
2-Pyrimidinecarboximidamide (9CI) is utilized as a building block in the synthesis of a variety of chemical compounds, highlighting its importance in the creation of diverse chemical entities for different applications.

Upstream product

• 14080-23-0 2-cyanopyrimidine 
• 917-64-6 methyl magnesium iodide 
• 60-29-7 diethyl ether 
• 88511-48-2 pyrimidine-2-carboxamide 
• 38275-60-4 5-bromo-pyrimidine-2-carboxylic acid amide 
• 4039-32-1 lithium hexamethyldisilazane 
• 89581-38-4 5-bromopyrimidine-2-carboxylic acid methyl ester 

Downstream Products

• 438249-96-8 2-(2-pyrimidinyl)-6-trifluoromethylpyrimidin-4-ol 
• 34671-83-5 2,2'-Bipyrimidine 
• 1426140-77-3 C₁₉H₁₂Cl₂N₆S 
• 1426140-17-1 1-phenyl-6-(phenylamino)-4-(pyrimidin-2-yl)-1,3,5-triazine-2(1H)-thione 
• 1446680-74-5 methyl 6-chloro-4-(3,4-difluorophenyl)-4-methyl-2-(pyrimidin-2-yl)-1,4-dihydropyrimidine-5-carboxylate 
• 3739-82-0 2-ethoxy-pyrimidine 
• 1187991-04-3 4-hydroxy-N-(2-phenylpropan-2-yl)-[2,2′-bipyrimidine]-5-carboxamide 

Relevant academic research and scientific papers

Elucidating the elusive crystal structure of 2,4,6-tris(2-pyrimidyl)-1,3,5-triazine

2,4,6-Tris(2-pyrimidyl)-1,3,5-triazine (TPymT) has been synthesized using two approaches: via trimerization of 2-cyanopyrimidine at 160 °C and by the reaction of 2-cyanopyrimidine with pyrimidine-2-carboximidamide. It was found that the two different synthetic pathways to TPymT yielded either a single polymorph or a mixture of two polymorphs; both of which were studied for the first time by X-ray powder diffraction (XRPD) and synchrotron X-ray powder diffraction (SXRPD). The crystal structure of the polymorph α-TPymT was determined by single crystal X-ray diffraction (SCXRD). Crystal structures of 2-cyanopyrimidine and pyrimidine-2-carboximidamide were also elucidated by SXRPD.

Novel Pyrimidine- And Triazine-Hepcidine Antagonists

The present invention relates to new hepcidin antagonists, pharmaceutical compositions containing them and the use thereof as a drug, in particular for the treatment of iron metabolism disorders such as, in particular, iron deficiency diseases and anaemia, in particular anaemia associated with chronic inflammatory disease (ACD: anaemia of chronic disease and AI: anaemia of inflammation).

Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: wherein A, Ar1, Ar2, R1 and R3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.