90993-49-0

Basic information

• Product Name: 2-Pyrimidinecarboximidamide,N-hydroxy-
• Synonyms: 2-Pyrimidinecarboximidamide,N-hydroxy-;2-Pyrimidinecarboximidamide, N-hydroxy- (9CI);N-Hydroxy-2-pyrimidinecarboximidamide
• CAS NO: 90993-49-0
• Molecular Formula: C₅H₆N₄O
• Molecular Weight: 138.12734
• Product Categories: PYRIMIDINE;pharmacetical
• Mol File: 90993-49-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 230-235℃
• Boiling Point: 410.9°Cat760mmHg
• Flash Point: 202.3°C
• Appearance: /
• Density: 1.49g/cm³
• CAS DataBase Reference: 2-Pyrimidinecarboximidamide,N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinecarboximidamide,N-hydroxy-(90993-49-0)
• EPA Substance Registry System: 2-Pyrimidinecarboximidamide,N-hydroxy-(90993-49-0)

Safety Data

• Hazardous Substances Data: 90993-49-0(Hazardous Substances Data)

Usage

General Description

N-hydroxy-2-pyrimidinecarboximidamide is a chemical compound with the molecular formula C5H6N4O and is commonly referred to as N-hydroxy-dicyandiamide. It is a white crystalline solid that is used as a curing agent for epoxy resins and as a hardener for amino resins in the production of heat-cured coatings and adhesives. N-hydroxy-dicyandiamide is also utilized in the synthesis of pharmaceuticals and as a stabilizer for chlorine-containing components in plastics. It is considered to be relatively nontoxic and non-hazardous to human health and the environment, with a low potential for bioaccumulation.

Upstream product

• 88511-48-2 pyrimidine-2-carboxamide 
• 14080-23-0 2-cyanopyrimidine 
• 38275-60-4 5-bromo-pyrimidine-2-carboxylic acid amide 
• 89581-38-4 5-bromopyrimidine-2-carboxylic acid methyl ester 

Downstream Products

• 1401223-33-3 N-isopropyl-2-(4-propylphenoxy)-N-((3-(pyrimidin-2-yl)-1,2,4-oxadiazol-5-yl)methyl)acetamide 
• 1001385-18-7 N-({2-[5-(4-fluorobenzyl)-3-pyridin-4-yl-1H-pyrazol-1-yl]acetyl}oxy)pyrimidine-2-carboximidamide 

Relevant articles and documents

New DNA-Interactive Manganese(II) Complex of Amidooxime: Crystal Structure, DFT Calculation, Biophysical and Molecular Docking Studies

A manganese(II) complex [MnII(HL1)2(Cl)(CH3COO)](1) based on the amidooxime ligand was synthesized and characterized by single-crystal X-ray diffraction studies, elemental analysis, UV-vis, and IR spectroscopy. The structural and spectral parameters were further supported using DFT/B3LYP. The complex (1) is mononuclear, having an octahedral geometry. The interaction of 1 with calf thymus DNA was investigated by spectroscopic and calorimetric techniques. The complex was found to interact with DNA through the groove-binding mode. From the isothermal titration calorimetry experiment, the binding constant between 1 and DNA was estimated to be (4.39 ± 0.01) × 105 M-1. The negative standard molar Gibbs energy change (δG0) and positive entropy (TδS0) values obtained from the calorimetry study confirmed the spontaneity of 1-DNA complexation. Thermodynamic parameters also suggested that the process of interaction of 1 with DNA was entropy-driven. The molecular docking study revealed that 1 binds at G30, C29, T31, A14, and G13 base pairs of the DNA chain in the minor groove.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

COMPOUNDS HAVING AN ETHR INHIBITING ACTIVITY - USE OF SAID COMPOUNDS AS DRUGS - PHARMACEUTICAL COMPOSITION AND PRODUCT CONTAINING SAID COMPOUNDS

The present invention relates to compounds of Formula (I), wherein R1 is chosen among the following radicals : (II); (III); (IV), (V), (VI) (VII) and n= 1 or 2 and m=1 or 2 with the proviso that m=2 when R1 is (VIII). The present invention also relates to the use thereof as drugs, more particularly in the treatment of mycobacterial infections and more particularly in the treatment of tuberculosis.