88529-79-7

Basic information

• Product Name: 1H-Pyrazole-3-carboxylicacid,1-methyl-,ethylester(9CI)
• Synonyms: 1H-Pyrazole-3-carboxylicacid,1-methyl-,ethylester(9CI);ethyl 1-Methyl-1H-pyrazole-3-carboxylate;Et 1-Methyl-1H-Pyrazole-3-carboxylate;1H-Pyrazole-3-carboxylic acid, 1-Methyl-, ethyl ester;1-Methyl-1H-pyrazole-3-carboxylic acid ethyl ester;1-methyl-3-pyrazolecarboxylic acid ethyl ester;1-methylpyrazole-3-carboxylic acid ethyl ester;ethyl 1-methylpyrazole-3-carboxylate
• CAS NO: 88529-79-7
• Molecular Formula: C7H10N2O2
• Molecular Weight: 154.17
• Product Categories: GLYCINESCAFFOLD
• Mol File: 88529-79-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 238.5±13.0℃ (760 Torr)
• Flash Point: 98.1±19.8℃
• Appearance: /
• Density: 1.14±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1H-Pyrazole-3-carboxylicacid,1-methyl-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3-carboxylicacid,1-methyl-,ethylester(9CI)(88529-79-7)
• EPA Substance Registry System: 1H-Pyrazole-3-carboxylicacid,1-methyl-,ethylester(9CI)(88529-79-7)

Safety Data

• Hazardous Substances Data: 88529-79-7(Hazardous Substances Data)

Usage

General Description

1H-Pyrazole-3-carboxylic acid, 1-methyl-, ethyl ester (9CI) is a chemical compound with the molecular formula C7H9N3O2. It is a methyl derivative of 1H-pyrazole-3-carboxylic acid, and is commonly used in organic synthesis and pharmaceutical research. 1H-Pyrazole-3-carboxylicacid,1-methyl-,ethylester(9CI) is a white solid with a melting point of 95-98°C, and has the potential to be used as a building block for the synthesis of various pharmaceuticals and agrochemicals. It has been studied for its potential biological activities, including anti-inflammatory and analgesic properties. However, further research is needed to fully understand its pharmacological potential and safety profile. Overall, 1H-Pyrazole-3-carboxylic acid, 1-methyl-, ethyl ester (9CI) is a versatile compound with potential applications in the fields of medicine and agriculture.

Upstream product

• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 
• 623-47-2 propynoic acid ethyl ester 
• 306-37-6 N,N'-Dimethylhydrazine dihydrochloride 
• 181427-25-8 ethyl (E)-4-(dimethylamino)-2-oxo-but-3-enoate 
• 64-17-5 ethanol 
• 59938-07-7 (3E)-1,1,1-trichloro-4-ethoxybut-3-en-2-one 
• 7339-53-9 methyl hydrazine hydrochloride 
• 256658-45-4 C₅H₁₄N₂OSi 

Downstream Products

• 1617523-40-6 C₁₇H₁₇F₃N₂O₃ 
• 1617523-39-3 C₁₄H₁₂ClF₃N₂O₃ 
• 1617523-37-1 C₁₅H₁₇N₃O₆ 
• 378203-86-2 ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate 
• 84547-62-6 (1-methyl-1H-pyrazol-3-yl)methanol 

Relevant articles and documents

METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae (I) (II) (III) (IV), wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

Regioselective synthesis of ethyl pyrazolecarboxylates from ethyl 3-[(dimethylamino)methylidene]pyruvate and diethyl 3-[(dimethylamino)methylidene]-2-oxosuccinate. Isolation of ethyl 4,5-dihydro-1-heteroaryl-5-hydroxy-1H-pyrazole-5-carboxylates as stable intermediates in the pyrazole ring formation

Reactions of ethyl 3-[(E)-(dimethylamino)methylidene]pyruvate (3) and 3-[(dimethylamino)methylidene]-2-oxosuccinate (4) with hydrazine monohydrochloride (5a) and (hetero)arylhydrazines (5b-i) afforded, regioselectively, 1-substituted ethyl 1H-pyrazole-5-carboxylates 9a-f and diethyl 1H-pyrazole-3,4-dicarboxylates, 11a-i, respectively. Upon treatment of 3 with pyridazinylhydrazines 5d-f, the stable intermediates, 1-substituted ethyl 4,5-dihydro-5-hydroxy-1H-pyrazole-5-carboxylates 8d-f, were isolated. Treatment of compounds 8d-f in acetic acid under reflux furnished the pyrazoles 9d-f. On the other hand, reaction of 3 with N,N′-dimethylhydrazine (5I) gave ethyl 1-methyl-1H-pyrazole-3-carboxylate (14). The structures of compounds 3, 4, 14 were determined by nmr (noesy and hmbc techniques), while the structures of compounds 8f, 9f, and 11e,f were determined by X-ray diffraction.

Haloacetylated enol ethers. 11 [16]. Synthesis of 1-methyl- and 1- phenyl pyrazole-3(5)-ethyl esters. A one-pot procedure

A one-pot synthesis of 1-methyl- and 1-phenylpyrazole-3(5)-ethyl esters 2,3a-e by the cyclocondensation of β-alkoxyvinyl trichloromethyl ketones 1a- e with methyl and phenyl hydrazine hydrochloride under mild conditions, is reported. A study using compounds la-e with different substituents proved that these are versatile building blocks for the synthesis of pyrazole derivatives, having a 3(5)-ethoxycarbonyl substituent in good yields (60- 89%). The hydrazine and β-alkoxyvinyl trichloromethyl ketone substituent effects on the reaction regiochemistry on the formation of the 1,3- and 1,5- isomer were observed.