886-46-4

Usage

Uses

Used in Pharmaceutical Research:
3-Piperidinemethanol, 4-hydroxy-1-(phenylmethyl)is used as a building block in the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure and functional groups make it a valuable component in the development of new drugs with diverse therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Piperidinemethanol, 4-hydroxy-1-(phenylmethyl)serves as an important intermediate for the preparation of a wide range of organic compounds. Its versatility in chemical reactions allows for the creation of various derivatives with specific properties and applications.
Used in Antimicrobial Applications:
3-Piperidinemethanol, 4-hydroxy-1-(phenylmethyl)has demonstrated antibacterial and antifungal activities, making it a potential candidate for the development of new drugs to treat infectious diseases. Its ability to target and inhibit the growth of harmful microorganisms could lead to the creation of novel antimicrobial agents.
Used in Pain Management:
Due to its potential analgesic properties, 3-Piperidinemethanol, 4-hydroxy-1-(phenylmethyl)is being studied for its use in pain management. It may be incorporated into formulations for the treatment of various types of pain, offering an alternative to existing analgesic medications.
Used in Antipsychotic Drug Development:
3-Piperidinemethanol, 4-hydroxy-1-(phenylmethyl)has shown potential antipsychotic properties, making it a candidate for the development of new antipsychotic drugs. Its ability to modulate neurotransmitter systems and alleviate psychiatric symptoms could contribute to the advancement of treatment options for mental health disorders.

Upstream product

• 956010-25-6 ethyl 1-benzyl-4-hydroxypiperidine-3-carboxylate 
• 41276-30-6 C₉H₁₄O₃NC₆H₅ 
• 1454-53-1 ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride 
• 57611-47-9 1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 

Downstream Products

• 252906-75-5 (+/-)-trans-3-(Hydroxymethyl)piperidin-4-ol 
• 252906-75-5 cis-3-hydroxymethyl-4-piperidinol 
• 252906-75-5 3-(Hydroxymethyl)piperidin-4-ol 
• 1360651-90-6 (-)-(1R,3R,6R)-8-benzyl-3-fluoro-2,4-dioxa-8-aza-3-phosphadecalin 3-oxide 
• 1360651-91-7 (+)-(1R,3S,6R)-8-benzyl-3-fluoro-2,4-dioxa-8-aza-3-phosphadecalin 3-oxide 
• 1360651-89-3 (-)-(1S,3R,6S)-8-benzyl-3-fluoro-2,4-dioxa-8-aza-3-phosphadecalin 3-oxide 
• 1360651-88-2 (+)-(1S,3S,6S)-8-benzyl-3-fluoro-2,4-dioxa-8-aza-3-phosphadecalin 3-oxide 
• 1360651-85-9 (-)-(1S,3R,6R)-8-benzyl-3-fluoro-2,4-dioxa-8-aza-3-phosphadecalin 3-oxide 
• 1360651-84-8 (-)-(1S,3S,6R)-8-benzyl-3-fluoro-2,4-dioxa-8-aza-3-phosphadecalin 3-oxide 
• 1360651-86-0 (+)-(1R,3R,6S)-8-benzyl-3-fluoro-2,4-dioxa-8-aza-3-phosphadecalin 3-oxide 
• 1360651-87-1 (+)-(1R,3S,6S)-8-benzyl-3-fluoro-2,4-dioxa-8-aza-3-phosphadecalin 3-oxide 
• 1135150-38-7 6-benzylhexahydro-2,2-dimethyl-4H-1,3-dioxino[5,4-c]pyridine 
• 1135150-39-8 6-benzylhexahydro-2,2-dimethyl-4H-1,3-dioxino[5,4-c]pyridine 
• 1135150-52-5 {(3R,4R)-1-benzyl-4-[(2S)-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropoxy]piperidin-3-yl}methyl (αS)-α-methoxy-α-(trifluoromethyl)-benzeneacetate 

Relevant academic research and scientific papers

HEPATITIS B ANTIVIRAL AGENTS

The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.

Synthesis and characterization of enantiomerically pure cis- and trans-3-fluoro-2,4-dioxa-8-aza-3-phosphadecalin 3-oxides as γ- homoacetylcholine mimetics and inhibitors of acetylcholinesterase

The title compounds, the P(3)-axially and P(3)-equatorially substituted cis- and trans-configured 8-benzyl-3-fluoro-2,4-dioxa-8-aza-3-phosphadecalin 3-oxides (=8-benzyl-3-fluoro-2,4-dioxa-8-aza-3-phosphabicyclo[4.4.0]decane 3-oxides=2-fluorohexahydro-6-(phenylmethyl)-4H-1,3,2-dioxaphosphorino[5,4-c] pyridine 2-oxides) were prepared (ee>98%) and fully characterized (Schemes2 and 3). The absolute configurations were established from that of their precursors, the enantiomerically pure cis- and trans-1-benzyl-4- hydroxypiperidine-3-methanols which were unambiguously assigned. Being configuratively fixed and conformationally constrained phosphorus analogues of acetyl γ-homocholine (=3-(acetyloxy)-N,N,N-trimethylpropan-1-aminium), they are suitable probes for the investigation of molecular interactions with acetylcholinesterase. As determined by kinetic methods, all of the compounds are weak inhibitors of the enzyme. Copyright

5-Quinoline derivatives having an anti-bacterial activity

The present invention describes novel anti-bacterial compounds of the formula (I). These compounds are, amongst others, of interest as inhibitors of DNA gyrase and topoisomerases, for example of topoisomerase II and IV.

QUINOLONE ANTIBACTERIAL AGENTS

Compounds of formula (I, II, III, IV, V, and VI) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula (I) as disclosed herein can be used in a variety of applications including use as antibacterial agents.

2,4-Dioxa-7-aza-, 2,4-dioxa-8-aza-, and 2,4-dioxa-9-aza-3-phosphadecalins as rigid acetylcholine mimetics: Syntheses and characterization

Phosphorylation of suitable piperidine precursors yielded a series of novel decalin-type O,N,P-heterocycles. The title compounds, P(3)-axially and P(3)-equatorially X-substituted, cis- and trans-configurated 2,4-dioxa-7-aza-, 2,4-dioxa-8-aza-, and 2,4-dioxa-9-aza-3-phosphabicyclo[4.4.0]decane 3-oxides (X = Cl, F, 4-nitrophenoxy, and 2,4-dinitrophenoxy), are configuratively fixed and conformationally constrained P-analogues of acetylcholine and as such represent acetylcholine (7-aza and 9-aza isomers) or γ-homo-acetylcholine mimetics (8-aza isomers). Being irreversible inhibitors of acetylcholinesterase (AChE), the compounds are considered to be suitable probes for the investigation of the stereochemical course of the inhibition reaction by 31P-NMR spectroscopy. Moreover, the design of these mimetics will enable studies of molecular interactions with AChE, in particular, the recognition conformation of acetylcholine.

INHIBITORS OF BACE

The present invention relates to inhibitors of aspartic proteinases, particularly, BACE. The present invention also relates to compositions thereof and methods therewith for inhibiting BACE activity in a mammal, and for treating Alzheimer's Disease and other BACE-mediated diseases.

Piperidine-renin inhibitors compounds with improved physicochemical properties

Piperidine renin inhibitors with heterocyclic core modifications or hydrophilic attachments show improved physical properties (lower lipophilicity, improved solubility). Tetrahydroquinoline derivative rac-30 with a molecular weight of 517 and a log D((pH 7.4)) of 1.9 displays potent and long lasting blood pressure lowering effects after oral administration to sodium depleted conscious marmosets.