886226-26-2

Upstream product

• 90-80-2 D-Glucono-1,5-lactone 
• 189825-51-2 2,3,4,6-tetra-O-(methoxymethyl)-δ-D-gluconolactone 
• 189825-52-3 (2R,3R,4S,5R)-3,4,5-tris(methoxymethoxy)-2-((methoxymethoxy)methyl)-6-methylenetetrahydro-2H-pyran 
• 116-31-4 all-trans-Retinal 
• 886226-23-9 2,6-anhydro-7-deoxy-7-[4-(bromomethyl)phenyl]-3,4,5-tri-O-acetyl-L-glycero-L-gulo-heptonic acid methyl ester 
• 886226-25-1 (2S,3S,4R,5S,6S)-3,4,5-Triacetoxy-6-{4-[(3E,5E,7E,9E)-2-(tert-butyl-dimethyl-silanyloxy)-2-cyano-4,8-dimethyl-10-(2,6,6-trimethyl-cyclohex-1-enyl)-deca-3,5,7,9-tetraenyl]-benzyl}-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 886226-24-0 retinal tert-butyl-dimethylsilylcyanohydrin 
• 886226-21-7 2,6-anhydro-1-deoxy-1-[4-(methoxymethyl)phenyl]-3,4,5,7-tetra-O-(methoxymethyl)-D-glycero-D-gulo-heptitol 
• 886226-20-6 2,6-anhydro-1-deoxy-1-[4-(hydroxymethyl)phenyl]-3,4,5,7-tetra-O-(methoxymethyl)-D-glycero-D-gulo-heptitol 
• 886226-22-8 2,6-anhydro-7-deoxy-7-[4-(methoxymethyl)phenyl]-3,4,5-tri-O-acetyl-L-glycero-L-gulo-heptonic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and preliminary chemotherapeutic evaluation of the fully C-linked glucuronide of N-(4-hydroxyphenyl)retinamide

All-trans retinoic acid analogues such as N-(4-hydroxyphenyl)retinamide (4-HPR) are effective chemopreventive and chemotherapeutic agents but their utility has been hampered by dose-limiting side effects. The glucuronide derivatives of 4-HPR, the oxygen-l

C-linked glucuronide of N-(4-hydroxybenzyl) retinone, analogs thereof, and method of using the same to inhibit neoplastic cell growth

Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans.