88636-91-3

Upstream product

• 96-49-1 [1,3]-dioxolan-2-one 
• 30806-83-8 p-ethoxycarbonylphenyl isocyanate 
• 208709-20-0 4-(2-chloro-ethoxycarbonylamino)-benzoic acid ethyl ester 
• 109-89-7 diethylamine 
• 497-25-6 dimethylenecyclourethane 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 94-09-7 p-aminoethylbenzoate 

Downstream Products

• 1223425-12-4 3-{4-[4-(2,4,6-trimethylphenyl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one 

Relevant academic research and scientific papers

NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE

Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis

Short and practical synthesis of N′,N′-disubstituted N-aryl-1,2-ethylene-diamines by a decarboxylative ring-opening reaction under nucleophilic conditions

A straightforward and practical synthesis of N′,N′- disubstituted N-aryl-1,2-ethylenediamines, starting from anilines, via N-aryloxazolidin-2-ones is described. A decarboxylative ring-opening reaction of N-aryloxazolidin-2-ones, using aliphatic secondary

Copper-catalyzed N-arylation of 2-oxazolidinones. An expeditious route to toloxatone

3-Aryl-2-oxazolidinones are obtained in excellent yields through the copper-catalyzed N-arylation of 2-oxazolidinones with a variety of aryl iodides. With aryl halides containing both iodo and bromo substituents, a high C-I/C-Br selectivity can be achieved. The procedure has been successfully applied to the preparation of a key intermediate in the synthesis of linezolid and to develop an expeditious route to toloxatone.