886503-15-7

Basic information

• Product Name: 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE
• Synonyms: 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE;Pyrrolidine, 2-(2,5-difluorophenyl)-
• CAS NO: 886503-15-7
• Molecular Formula: C₁₀H₁₁F₂N
• Molecular Weight: 183.2
• Mol File: 886503-15-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 213.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.164±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.02±0.10(Predicted)
• CAS DataBase Reference: 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE(886503-15-7)
• EPA Substance Registry System: 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE(886503-15-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 886503-15-7(Hazardous Substances Data)

Usage

General Description

2-(2,5-Difluoro-phenyl)-pyrrolidine is a chemical compound with the molecular formula C10H11F2N. It is a pyrrolidine derivative with a 2,5-difluorophenyl group attached to the nitrogen atom. 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE has potential applications in medicinal chemistry and pharmaceuticals due to its structural features and potential biological activities. It may possess interesting pharmacological properties, such as antifungal or antibacterial activities, making it a potentially valuable compound for drug development efforts. The specific properties and potential uses of 2-(2,5-difluoro-phenyl)-pyrrolidine would require further research and investigation.

Upstream product

• 540-36-3 para-difluorobenzene 
• 1217630-38-0 (S)-(–)-2-(2,5-difluorophenyl)pyrrolidine 
• 1196551-99-1 tert-butyl 2-(2,5-difluorophenyl)-2-hydroxypyrrole-1-carboxylate 
• 5724-81-2 1-pyrroline 
• 399-94-0 2-bromo-1,4-difluorobenzene 
• 1443538-33-7 tert-butyl 5-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate 
• 1443623-92-4 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole 

Downstream Products

• 1196551-98-0 3-bromo-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine 
• 1443538-90-6 5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid 
• 1443538-89-3 ethyl 5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate 

Relevant articles and documents

Racemization method of larotinib intermediate

The invention discloses a racemization method of a larotinib intermediate, which comprises the following steps: in a solvent, heating (2S)-2-(2, 5-difluorophenyl)pyrrolidine(compound I, S-type I) or aracemic mixture mainly comprising S-type I, and convert

Method for preparing larotrectinib intermediate through one-pot method

The invention discloses a method for preparing a larotrectinib intermediate through a one-pot method. The preparation method is characterized by comprising the following steps: 1) dissolving a compound VI serving as a raw material in a solvent, adding isopropyl magnesium chloride to generate a Grignard reagent, and reacting with N-Boc-pyrrolidone to obtain a compound I; 2) adding an acid into thereaction solution, and carrying out a Boc removal reaction on the compound I to obtain a compound II; 3) adding an alkali into the reaction solution, and carrying out a ring closing reaction on the compound II to obtain a compound III; 4) carrying out reduction on the compound III in the reaction solution to obtain a compound IV; and 5) carrying out salification on the compound IV and D-malic acid, and re-crystallizing to obtain a compound V.

Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases

Exploring a collection of naturally occurring imine reductases (IREDs) identified two stereocomplementary IREDs with reducing activity toward sterically hindered 2-aryl-substituted pyrrolines. Using (R)-selective ScIR and (S)-selective SvIR, various chiral 2-aryl-substituted pyrrolidines with excellent enantioselectivity (>99% ee) were stereocomplementarily synthesized in good yield (60-80%), demonstrating the feasibility of IREDs for generating pharmaceutically relevant chiral 2-aryl-substituted pyrrolidine intermediates.