88701-59-1

Basic information

• Product Name: 2-Thiopheneacetonitrile, a-methyl-
• Synonyms: '(Thienyl-2)methylacetonitrile', 2--propionsaeure-nitril;2-(2-thienyl)propionitrile;2-[2]thienyl-propionitrile;2-Thiophen-2-yl-propionitrile;2-[2]Thienyl-propionitril;
• CAS NO: 88701-59-1
• Molecular Formula: C7H7NS
• Molecular Weight: 137.205
• Mol File: 88701-59-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 117 °C (20 mmHg)
• Density: 1.121±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Thiopheneacetonitrile, a-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiopheneacetonitrile, a-methyl-(88701-59-1)
• EPA Substance Registry System: 2-Thiopheneacetonitrile, a-methyl-(88701-59-1)

Safety Data

• Hazardous Substances Data: 88701-59-1(Hazardous Substances Data)

Upstream product

• 20893-30-5 2-cyanomethylthiophene 
• 67-56-1 methanol 
• 557-21-1 zinc(II) cyanide 
• 115510-91-3 1-(thien-2-yl)ethanol 
• 765-50-4 2-Chloromethylthiophene 
• 616-38-6 carbonic acid dimethyl ester 
• 45438-73-1 2-thenyl bromide 
• 554-14-3 2-Methylthiophene 
• 28612-98-8 2-chloro-2-(2-thienyl)ethane 
• 7677-24-9 trimethylsilyl cyanide 
• 34312-77-1 1-(2-thienyl)-2-nitroethene 
• 1402167-02-5 rac-2-(1-nitropropan-2-yl)thiophene 
• 98-03-3 thiophene-2-carbaldehyde 
• 13781-53-8 (thiophen-3-yl)acetonitrile 

Downstream Products

• 33005-95-7 tiaprofenic acid 

Relevant articles and documents

Rhenium(I)-Catalyzed C-Methylation of Ketones, Indoles, and Arylacetonitriles Using Methanol

A ReCl(CO)5/MeC(CH2PPh2)3 (L2) system was developed for the C-methylation reactions utilizing methanol and base, following the borrowing hydrogen strategy. Diverse ketones, indoles, and arylacetonitriles underwent mono-and dimethylation selectively up to 99% yield. Remarkably, tandem multiple methylations were also achieved by employing this catalytic system.

Nickel-Catalyzed Cyanation of Benzylic and Allylic Pivalate Esters

A nickel-catalyzed cyanation reaction of benzylic and allylic pivalate esters is reported using an air-stable Ni(II) precatalyst and substoichiometric quantities of Zn(CN)2. Alkene additives were found to inhibit catalysis, suggesting that avoiding β-hydride elimination side reactions is essential for productive catalysis. An enantioenriched allylic ester undergoes enantiospecific cross-coupling to produce an enantioenriched allylic nitrile. This method was applied to an efficient synthesis of (±)-naproxen from commercially available starting materials.

Preparation method of non-steroidal anti-inflammatory drug tiaprofenic acid

The invention relates to a preparation method of non-steroidal anti-inflammatory drug tiaprofenic acid. The preparation method includes: taking 2-chloromethyl thiophene as a starting raw material; synthesizing thiophene-2-acetonitrile by allowing 2-chloromethyl thiophene to react with trimethylsilyl cyanide; allowing thiophene-2-acetonitrile to react with dimethyl carbonate for methylation prior to cyan-hydrolysis; finally, performing benzoyl chloroformylation reaction to obtain tiaprofenic acid. The preparation method has the advantages that rare, valuable and dangerous materials are replacedwith common, cheap and safe raw materials, serious pollution problems are avoided, and production cost is greatly reduced; in addition, the process adopted in the method is short in route, short in reaction period, stable in reaction condition and high in yield which can be up to 90%, the product obtained is high in purity which can reach above 99%, and the preparation method is applicable to industrial production.