887250-03-5Relevant academic research and scientific papers
Immunomodulator
-
, (2021/05/22)
The invention discloses an immunomodulator, and particularly relates to a compound for inhibiting IL-17A and application of the compound serving as the immunomodulator in preparation of drugs. The invention discloses application of a compound shown in a f
SPIROCYCLIC INDANE ANALOGUES AS IL-17 MODULATORS
-
, (2020/02/06)
A series of substituted spirocyclic indane derivatives of Formula (I), and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory
SPIROCYCLIC INDOLINES AS IL-17 MODULATORS
-
, (2019/01/07)
A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups
Sparks, Steven M.,Banker, Pierette,Bickett, David M.,Carter, H. Luke,Clancy, Daphne C.,Dickerson, Scott H.,Dwornik, Kate A.,Garrido, Dulce M.,Golden, Pamela L.,Nolte, Robert T.,Peat, Andrew J.,Sheckler, Lauren R.,Tavares, Francis X.,Thomson, Stephen A.,Wang, Liping,Weiel, James E.
scheme or table, p. 976 - 980 (2009/09/25)
Optimization of the amino acid residue within a series of anthranilimide-based glycogen phosphorylase inhibitors is described. These studies culminated in the identification of anthranilimides 16 and 22 which displayed potent in vitro inhibition of GPa in
