88744-36-9

Usage

Uses

Used in Pharmaceutical Industry:
AMINO-(2-CHLORO-PHENYL)-ACETIC ACID is used as an intermediate in the synthesis of pharmaceuticals for its potential therapeutic uses. It serves as a building block in the development of new drugs, particularly those targeting bacterial and fungal infections, as well as conditions that benefit from its anti-inflammatory and analgesic properties.
Used in Agrochemical Industry:
In the agrochemical sector, AMINO-(2-CHLORO-PHENYL)-ACETIC ACID is utilized as a precursor in the production of agrochemicals. Its biological activities make it a valuable component in the creation of pesticides and fungicides, helping to protect crops from various pathogens and pests, thereby ensuring a stable food supply.
Used in Antibacterial Applications:
AMINO-(2-CHLORO-PHENYL)-ACETIC ACID is used as an antibacterial agent for its ability to inhibit the growth of bacteria, making it a potential candidate for the development of new antibiotics to combat drug-resistant bacterial strains.
Used in Antifungal Applications:
AMINO-(2-CHLORO-PHENYL)-ACETIC ACID is also used as an antifungal agent, leveraging its ability to prevent the growth of fungi, which is particularly important in both medical and agricultural settings to control fungal infections and protect crops from fungal diseases.
Used in Anti-inflammatory and Analgesic Formulations:
AMINO-(2-CHLORO-PHENYL)-ACETIC ACID is used as an active ingredient in anti-inflammatory and analgesic formulations, capitalizing on its capacity to reduce inflammation and alleviate pain, offering relief in various medical conditions.

Upstream product

• 103029-09-0 5-(2-chlorophenyl)imidazolidine-2,4-dione 
• 13312-84-0 2-chloromandelonitrile 
• 144616-14-8 ortho-chlorophenylmalonic acid 
• 187243-26-1 N-(o-chlorophenyl)hydantoin 
• 143-33-9 sodium cyanide 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 92874-69-6 DL-Benzyloxycarbonylamino-<2-chlor-phenyl>-essigsaeure 
• 141109-14-0 2-(2-chlorophenyl)glycine methyl ester hydrochloride 
• 1276118-73-0 C₁₁H₁₃ClN₂O 
• 1276118-74-1 C₁₂H₁₅ClN₂O 
• 1276118-75-2 C₁₃H₁₇ClN₂O 
• 1276118-81-0 C₁₆H₁₄ClNO₂ 
• 1313411-65-2 C₁₉H₁₇ClN₂O₂ 
• 1276118-82-1 C₁₂H₁₃ClN₂O₂ 
• 1276118-83-2 C₁₉H₁₉ClN₂O₃ 
• 1276118-85-4 C₂₁H₂₃ClN₂O₃ 
• 1276118-84-3 C₂₀H₂₁ClN₂O₃ 
• 17099-11-5 N-(4-methoxyphenyl)-2-chlorobenzylidenimine 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 89-98-5 2-chloro-benzaldehyde 

Relevant academic research and scientific papers

Method for continuously and quickly preparing DL-phenylglycine and analogue thereof

The invention provides a method for continuously and quickly preparing DL-phenylglycine and an analogue thereof. The method comprises the steps of adding 2-hydroxyl-phenylacetonitrile and an analoguethereof (cyanohydrin for short) and an aqueous ammonium bicarbonate solution into a microchannel reactor for a reaction, controlling the reaction temperature to be 80-130 DEG C, and controlling the reaction pressure to be 0.5-2.0 MPa, wherein the standing time of the reactants in a microchannel is 1-8 min, and an aqueous solution of 5-phenyl-hydantoin and an analogue thereof (hydantoin for short)is obtained; adding the hydantoin and alkali into the microchannel reactor for a reaction, controlling the reaction temperature to be 120-200 DEG C, and controlling the reaction pressure to be 1.0-3.5MPa, wherein the standing time of the reactants in the microchannel is 1-8 min, and then a saline solution of phenylglycine and an analogue thereof is obtained; conducting acidification neutralization and crystallization to obtain the phenylglycine and the analogue thereof. According to the method, the microchannel reactor is adopted, the reaction time is greatly shorted, the reaction speed is increased, pyrolysis and polymerization of the cyanohydrin are reduced, no by-products are generated, the products are high in yield, clean and environmentally friendly, and the production cost is lowered.

Preparation method for D, L-phenylglycine and analogue thereof

The invention provides a preparation method for D, L-phenylglycine and an analogue thereof. According to the method, benzaldehyde, an analogue thereof and hydrocyanic acid are adopted as raw materials and subjected to cyanidation reaction, and then 2-hydroxy-benzyl cyanide or 2-hydroxy-benzyl cyanide analogue (cyanohydrin for short) is generated. Cyanohydrin reacts with carbon dioxide and the aqueous solution of ammonia, and then 5-phenyl-hydantoin and an analogue thereof (hydantoin for short) are generated. hydantoin is successively subjected to steam stripping, alkaline hydrolysis, steam stripping, decolorization, neutralization, crystallization, washing, centrifuging, drying and the like to obtain D, L-phenylglycine and the analogue thereof. Compared with the prior art, the preparation method for D, L-phenylglycine and the analogue thereof can significantly and effectively reduce the pollution, and fewer inorganic salt by-products are generated. Meanwhile, the prepared D, L-phenylglycine and the analogue thereof are high in product yield and high in purity. Counted in benzaldehyde and the analogue thereof, the yield of D, L-phenylglycine and the analogue thereof is larger than or equal to 96%, and the product purity is larger than or equal to 99%. Meanwhile, the process flow is simple and feasible, so that the method is worthy of market popularization and application.

Process for preparation of 2-chlorophenylglycine derivatives and enantiomerically separation

The present invention relates to novel processes and intermediates for the preparation of R(?)-α-2-chlorophenylglycine, S(+)-α-2-chlorophenylglycine, and RS-2-chlorophenylglycine derivatives of formulas I, II and III, respectively. The resulting enantioseparative system was validated in order to evaluate the presence of the enantiomer in pharmaceutical samples. These compounds are found useful as an active ingredient for the pharmaceutical intermediate or as an active ingredient as the tools for delivery of drugs.