88744-36-9

Basic information

• Product Name: AMINO-(2-CHLORO-PHENYL)-ACETIC ACID
• Synonyms: DL-2-CHLOROPHENYLGLYCINE;(+/-)-2-CHLOROPHENYLGLYCINE;2-CHLOROPHENYLGLYCINE;2-CHLORO-DL-PHENYLGLYCINE;AMINO-(2-CHLORO-PHENYL)-ACETIC ACID;(+/-)-ALPHA-AMINO-2-CHLOROPHENYLACETIC ACID;RARECHEM AK ML 0504;O-CHLORO-A-AMINOPHENYLACETIC ACID
• CAS NO: 88744-36-9
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Product Categories: Amino ACIDS SERIES;pharmacetical;Benzene series
• Mol File: 88744-36-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 218-220 °C (decomp)
• Boiling Point: 318.8 °C at 760 mmHg
• Flash Point: 146.6 °C
• Appearance: White to off-white/Powder
• Density: 1.392 g/cm³
• Storage Temp.: Store under inert gas
• PKA: 1.69±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: AMINO-(2-CHLORO-PHENYL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: AMINO-(2-CHLORO-PHENYL)-ACETIC ACID(88744-36-9)
• EPA Substance Registry System: AMINO-(2-CHLORO-PHENYL)-ACETIC ACID(88744-36-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• F: 10-23
• Hazardous Substances Data: 88744-36-9(Hazardous Substances Data)

Usage

General Description

AMINO-(2-CHLORO-PHENYL)-ACETIC ACID, also known as 2-chlorophenylglycine, is a chemical compound with the molecular formula C8H8ClNO2. It is an amino acid derivative that contains a chlorine atom and a phenyl group. AMINO-(2-CHLORO-PHENYL)-ACETIC ACID is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has various biological activities and has been studied for its potential therapeutic uses, including as an antibacterial and antifungal agent. Additionally, it has been found to exhibit anti-inflammatory and analgesic properties. Overall, AMINO-(2-CHLORO-PHENYL)-ACETIC ACID is a versatile chemical with potential applications in the pharmaceutical and agricultural industries.

Upstream product

• 103029-09-0 5-(2-chlorophenyl)imidazolidine-2,4-dione 
• 143-33-9 sodium cyanide 
• 89-98-5 2-chloro-benzaldehyde 
• 13312-84-0 2-chloromandelonitrile 
• 187243-26-1 N-(o-chlorophenyl)hydantoin 
• 144616-14-8 ortho-chlorophenylmalonic acid 

Downstream Products

• 111-85-3 n-chlorooctane 
• 131402-95-4 Amino-(2-chloro-phenyl)-acetic acid octyl ester; hydrochloride 
• 92874-69-6 DL-Benzyloxycarbonylamino-<2-chlor-phenyl>-essigsaeure 
• 141109-16-2 α-amino-(2-chlorophenyl)acetic acid methyl ester 
• 141109-17-3 (+/-)-2-chlorophenylglycine methyl ester hydrochloride 
• 500772-75-8 ethyl 2-amino-2-(2-chlorophenyl)acetate 
• 138647-05-9 2-bromo-2-(2-chlorophenyl)acetyl chloride 
• 89-98-5 2-chloro-benzaldehyde 

Relevant articles and documents

Method for continuously and quickly preparing DL-phenylglycine and analogue thereof

The invention provides a method for continuously and quickly preparing DL-phenylglycine and an analogue thereof. The method comprises the steps of adding 2-hydroxyl-phenylacetonitrile and an analoguethereof (cyanohydrin for short) and an aqueous ammonium bicarbonate solution into a microchannel reactor for a reaction, controlling the reaction temperature to be 80-130 DEG C, and controlling the reaction pressure to be 0.5-2.0 MPa, wherein the standing time of the reactants in a microchannel is 1-8 min, and an aqueous solution of 5-phenyl-hydantoin and an analogue thereof (hydantoin for short)is obtained; adding the hydantoin and alkali into the microchannel reactor for a reaction, controlling the reaction temperature to be 120-200 DEG C, and controlling the reaction pressure to be 1.0-3.5MPa, wherein the standing time of the reactants in the microchannel is 1-8 min, and then a saline solution of phenylglycine and an analogue thereof is obtained; conducting acidification neutralization and crystallization to obtain the phenylglycine and the analogue thereof. According to the method, the microchannel reactor is adopted, the reaction time is greatly shorted, the reaction speed is increased, pyrolysis and polymerization of the cyanohydrin are reduced, no by-products are generated, the products are high in yield, clean and environmentally friendly, and the production cost is lowered.

Process for preparation of 2-chlorophenylglycine derivatives and enantiomerically separation

The present invention relates to novel processes and intermediates for the preparation of R(?)-α-2-chlorophenylglycine, S(+)-α-2-chlorophenylglycine, and RS-2-chlorophenylglycine derivatives of formulas I, II and III, respectively. The resulting enantioseparative system was validated in order to evaluate the presence of the enantiomer in pharmaceutical samples. These compounds are found useful as an active ingredient for the pharmaceutical intermediate or as an active ingredient as the tools for delivery of drugs.