887587-99-7 Usage
Chemical Class
Piperidine derivative
Explanation
It is a compound derived from piperidine, which is a heterocyclic compound containing a six-membered ring.
Explanation
The BOC (tert-butoxycarbonyl) group is used to protect amines, while the fluorophenylamino group contributes to its potential pharmacological properties.
Explanation
It is used in the synthesis of various pharmaceuticals, particularly for the development of drugs targeting neurological and psychiatric disorders.
Explanation
1-BOC-2-[(4-FLUORO-PHENYLAMINO)-METHYL]-PIPERIDINE serves as an intermediate compound in the production of different drugs.
Explanation
The piperidine ring is a six-membered ring containing one nitrogen atom, which is a key structural feature of 1-BOC-2-[(4-FLUORO-PHENYLAMINO)-METHYL]-PIPERIDINE.
Explanation
The BOC group is used to protect the amine functionality in the molecule, preventing unwanted reactions during the synthesis process.
Explanation
The fluorophenylamino group is a substituent attached to the piperidine ring, which may contribute to the compound's pharmacological properties.
Explanation
The presence of a fluorine atom in the phenyl ring of the fluorophenylamino substituent can influence the compound's reactivity, stability, and pharmacological properties.
Explanation
Due to its structural features and the presence of the fluorophenylamino group, 1-BOC-2-[(4-FLUORO-PHENYLAMINO)-METHYL]-PIPERIDINE is often used in the development of new pharmaceuticals for the treatment of neurological and psychiatric disorders.
Explanation
1-BOC-2-[(4-FLUORO-PHENYLAMINO)-METHYL]-PIPERIDINE is synthesized using various organic synthesis techniques, taking advantage of the reactivity of the functional groups present in the molecule.
Functional Groups
BOC protecting group and fluorophenylamino substituent
Application
Pharmaceutical synthesis
Role
Intermediate in drug production
Structural Feature
Six-membered nitrogen-containing ring
Protecting Group
BOC
Substituent
Fluorophenylamino
Fluorine Atom
Present in the phenyl ring
Potential Use
Treatment of neurological and psychiatric disorders
Synthesis
Organic synthesis techniques
Check Digit Verification of cas no
The CAS Registry Mumber 887587-99-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,7,5,8 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 887587-99:
(8*8)+(7*8)+(6*7)+(5*5)+(4*8)+(3*7)+(2*9)+(1*9)=267
267 % 10 = 7
So 887587-99-7 is a valid CAS Registry Number.
887587-99-7Relevant academic research and scientific papers
PYRIDINE- AND PYRIMIDINECARBOXAMIDES AS CXCR2 MODULATORS
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Paragraph 0173, (2015/11/27)
There is disclosed pyridine-and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine-and pyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.
Discovery of 2-[5-(4-fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic acid (SX-517): Noncompetitive boronic acid antagonist of CXCR1 and CXCR2
Maeda, Dean Y.,Peck, Angela M.,Schuler, Aaron D.,Quinn, Mark T.,Kirpotina, Liliya N.,Wicomb, Winston N.,Fan, Guo-Huang,Zebala, John A.
, p. 8378 - 8397 (2014/12/11)
The G protein-coupled chemokine receptors CXCR1 and CXCR2 play key roles in inflammatory diseases and carcinogenesis. In inflammation, they activate and recruit polymorphonuclear cells (PMNs) through binding of the chemokines CXCL1 (CXCR1) and CXCL8 (CXCR1 and CXCR2). Structure-activity studies that examined the effect of a novel series of S-substituted 6-mercapto-N-phenyl-nicotinamides on CXCL1-stimulated Ca2+ flux in whole human PMNs led to the discovery of 2-[5-(4-fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic acid (SX-517), a potent noncompetitive boronic acid CXCR1/2 antagonist. SX-517 inhibited CXCL1-induced Ca2+ flux (IC50 = 38 nM) in human PMNs but had no effect on the Ca2+ flux induced by C5a, fMLF, or PAF. In recombinant HEK293 cells that stably expressed CXCR2, SX-517 antagonized CXCL8-induced [35S]GTPγS binding (IC50 = 60 nM) and ERK1/2 phosphorylation. Inhibition was noncompetitive, with SX-517 unable to compete the binding of [125I]-CXCL8 to CXCR2 membranes. SX-517 (0.2 mg/kg iv) significantly inhibited inflammation in an in vivo murine model. SX-517 is the first reported boronic acid chemokine antagonist and represents a novel pharmacophore for CXCR1/2 antagonism.
Pyridine- and Pyrimidinecarboxamides as CXCR2 Modulators
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Page/Page column 48, (2010/08/22)
There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.
