888-33-5

Upstream product

• 780-25-6 N-benzylidene benzylamine 
• 98-86-2 acetophenone 
• 63765-03-7 (1S,4S)-2-[benzylimino]-1,7,7-trimethylbicyclo[2.2.1]heptane 
• 917-64-6 methyl magnesium iodide 
• 24277-44-9 (1-isothiocyanato-ethyl)-benzene 
• 917965-96-9 5-methyl-4,5-diphenyloxazolidine-2-thione 
• 80960-99-2 1,2-Diphenyl-1-{[1-phenyl-meth-(E)-ylidene]-amino}-propan-2-ol 

Downstream Products

• 917965-98-1 C₁₉H₂₁NO₂ 
• 36746-51-7 (+/-)-5t-methyl-2,4r,5c-triphenyl-4,5-dihydro-oxazole 
• 36746-51-7 (+/-)-5c-methyl-2,4r,5t-triphenyl-4,5-dihydro-oxazole 
• 110664-12-5 benzoic acid-((1RS,2RS)-2-amino-1-methyl-1,2-diphenyl-ethyl ester); hydrochloride 
• 111584-97-5 N-((1RS,2RS)-2-chloro-1,2-diphenyl-propyl)-benzamide 
• 36746-52-8 (+/-)-2,5t-dimethyl-4r,5c-diphenyl-4,5-dihydro-oxazole 
• 108976-11-0 N-((1RS,2SR)-2-hydroxy-1,2-diphenyl-propyl)-acetamide 

Relevant academic research and scientific papers

SUBSTITUTED PYRR0LIDIN-2-0NES , PIPERIDIN-2-0NES AND ISOTHIAZOLIDINE-1, 1-DIOXIDES, THEIR USE AS KVl .5 POTASSIUM CHANNEL BLOCKERS AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM

The invention relates to compounds of the formula (I), in which A, R1 , R2, R3, R4, R5, R6, R7 and n have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for the treatment and prophylaxis of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.

ASYMMETRIC SYNTHESES VI: ASYMMETRIC ALDOL REACTION OF D-CAMPHOR IMINE DERIVED FROM BENZYLAMINE

Addition of the D-camphor imine of benzylamine to a variety of aldehydes or ketones gives diastereoselectivites ranging from 16-70percent.The d.e. value is attributed by the difference of the orientation of C-11 groups.The rotation of (5e) indicates that addition reaction occurs from the pro-R face of lithium derivative (2).

METALLATION OF BENZYLIDENEBENZYLAMINE

The reactions of benzylidenebenzylamine with methyllithium and lithium diethylamide were investigated by GLC.Products with different structures from condensation of the azomethine are formed: Cyclic 2,4,5-triphenyl-3-benzylimidazolidine and noncyclic dibenzylidene-1,2-diphenylethylenediamine.Investigation of the effects of the solvent, temperature, and ratio of reagents on the reaction made it possible to obtain conditions for synthetic application of the 1,3-diphenylazaallyllithium, obtained by metallation of benzylidenebenzylamine, in reactions with alkyl halides, carbon dioxide, carbonyl compounds, and phenyl isocyanate.These conditions involve a temperature between -60 and -70 deg C and an equimolar ratio between the reagents.