88848-79-7

Usage

InChI:InChI=1/C35H51NO5/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-23-19-22(15-17-33(23,4)27(24)16-18-34(25,26)5)30-31(39)36(41)32(40)35(30)28(37)13-14-29(35)38/h9,20-22,24-27,30,41H,6-8,10-19H2,1-5H3/t21-,22?,24?,25-,26?,27?,30?,33+,34-/m1/s1

Upstream product

• 57-88-5 cholesterol 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 1510-21-0 cholesteryl hemisuccinate 

Downstream Products

• 91202-79-8 N-methyl>-N^α-<4-(5-cholesten-5β-yloxy)succinyl>glycinamide 
• 91208-73-0 C₄₉H₈₂N₂O₁₇ 

Relevant academic research and scientific papers

MONOSACCHARIDE-TAGGED NANO-LIPOSOME DRUG DELIVERY SYSTEM, THE MANUFACTURE AND USE FOR DRUG TARGETING DELIVERY THEREOF

The present invention relates to a monosaccharide-tagged nano-liposome, which is characterized that the targeting monosaccharide is conjugated to cholesterol and the monosaccharide-conjugated cholesterol is incorporate into the phospholipid bilayer. The nano-liposome of present invention exhibits the ability to carry the loaded drug to target cells, such as cancer cells and cancer stem cells in a tumor tissue, and be internalized by endocytosis to produce direct cytotoxicity or suppress stemness gene expression, so as to avoid toxicity to normal cells and effectively improve the therapeutic effect of cancer clinical medication and radiation therapy.

Hydrolytically releasable prodrugs for sustained release nanoparticle formulations

A prodrug according to formula (I) wherein R2 is a residue of a drug, said drug having a hydroxyl group by which the COOR2 group is formed; Z is O or NH; m is 0 or 1; and R3 is an organic moiety comprising a lipophilic gro

OLIGOMER-CONTAINED NANOPARTICLE COMPLEX RELEASE SYSTEM

An oligomer-contained nanoparticle complex is provided. The oligomer-contained nanoparticle complex of the invention comprises (a) a nanoparticle, (b) a polymer with high molecule weigh, (c) a target molecule, (d) an oligomer, wherein the oligomer is crosslinked with the polymer by the intermolecular hydrogen bonds or electron bonds, and e) a space for active substances, wherein the space for active substances is encapsulated by the nanoparticle. The oligomer-contained nanoparticle complex of the invention has the high stability and fast drug release rate, and would not be largely accumulated in normal tissues. The invention also provides a method for preparing the oligomer-contained nanoparticle complex and the method for releasing drug.

Systematic exploration of lipophilic tags that allow efficient anchoring of aptamers to live cell surfaces

We carried out a systematic exploration of lipophilic tag molecules that allow efficient anchoring of aptamers to live cell surfaces. Among the lipids tested, the C16 dialkyl (dipalmitoylphosphatidylethanolamine) tag showed a good performance: a high anchoring yield and long retention on live cells. The 3'-C16 dialkyl tag-labeled fluorescent aptamer sensor, targeting thrombin, was prepared. The aptamer sensor was anchored successfully to live cells, allowing fluorescence detection of thrombin on the cell surface.

Synthesis of neoglycolipids containing oligosaccharides based on 3,6-branched-α-D-mannopyranosides as the carbohydrate moieties

Several oligosaccharides containing 3,6-branched-α-D-mannopyranosides were obtained by selective glycosylation of 5-azido-3-oxapentyl α-D-mannopyranoside with acetobromosugars. After deacetylation and reduction of the spacer azido group, the oligosacchari

A water-soluble cholesteryl-containing trisgalactoside: Synthesis, properties, and use in directing lipid-containing particles to the liver

The synthesis of a trisgalactoside-terminated cholesterol derivative is described. Tris(galactosyloxymethyl)-aminomethane is coupled to cholesterol by using glycyl and succinyl as intermediate hydrophilic spacer moieties. The resulting cholesteryl ester d