88928-69-2

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of complex molecular structures. It plays a crucial role in the development of new medications, enhancing the therapeutic potential of various drug classes.
Used in Organic Chemical Reactions:
As an intermediate in organic chemical reactions, methyl 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate is employed to facilitate the formation of desired products through esterification, amidation, and other chemical processes. Its reactivity and structural features make it a versatile component in organic synthesis.
Used in Research and Development:
In the realm of research and development, methyl 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate is utilized as a building block for the creation of novel drug candidates. Its unique structure allows for the exploration of new chemical entities with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Chemical Laboratories:
Methyl 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate is commonly found in chemical labs, where it is employed in a variety of experimental procedures. Its presence in these settings is essential for the synthesis and analysis of complex organic compounds, supporting the ongoing work of chemists and researchers in the field.

Upstream product

• 6516-41-2 1-benzyl-3-(methoxycarbonyl)pyridinium bromide 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 100-39-0 benzyl bromide 
• 955998-64-8 methyl 1-benzyl-4-hydroxypiperidine-3-carboxylate 
• 6197-39-3 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid methyl ester hydrochloride 
• 63-75-2 arecoline 
• 300-08-3 arecoline hydrobromide 
• 100-46-9 benzylamine 
• 793-19-1 bis(2-methoxycarbonylethyl)benzylamine 
• 57611-47-9 1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 

Downstream Products

• 857051-22-0 methyl 1-benzyl-3-butyl-1,2,3,6-tetrahydropyridine-3-carboxylate 
• 857051-23-1 1-benzyl-3-butyl-1,2,3,6-tetrahydropyridine-3-carbaldehyde 
• 857051-26-4 (1-benzyl-3-butyl-1,2,3,6-tetrahydropyridin-3-yl)methylamine 
• 857051-42-4 (1-benzyl-3-butyl-1,2,3,6-tetrahydro-pyridin-3-ylmethyl)-butyl-amine 
• 857051-36-6 N-[(1-benzyl-3-butyl-1,2,3,6-tetrahydropyridin-3-yl)methyl]-2,2,2-trifluoroacetamide 
• 857051-27-5 N-((1-benzyl-3-butyl-1,2,3,6-tetrahydropyridin-3-yl)methyl)-N-butyl-2,2,2-trifluoroacetamide 
• 1452108-88-1 sodium 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate 
• 252056-58-9 dimethyl 4-(4-fluorophenyl)-1,4,5,6-tetrahydropyridine-1,3-dicarboxylate 
• 955998-65-9 methyl 4-(4-fluorophenyl)-1,4,5,6-tetrahydropyridine-3-carboxylate 

Relevant academic research and scientific papers

N-Heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylic acid a novel scaffold for the design of uncompetitive α-glucosidase inhibitors

Abstract The enzyme α-glucosidase has attracted interest owing to its involvement in the digestive process of carbohydrate, its role in intracellular glycoprotein trafficking, tumorigenesis and viral infection. In this study, several members of a new family of N-heteroarylmethyl substituted azasugars were synthesized and evaluated as α-glucosidase inhibitors. We systematically investigated the effect of different N-substituents as well as the role of hydroxyl and carboxylate moieties on the piperidine ring. The compounds N-heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylic acid emerged as potent α-glucosidase inhibitors. Unlike Acarbose and other clinically relevant α-glucosidase inhibitors, these compounds act through a reversible uncompetitive mechanism of inhibition which make them attractive candidates for drug development.

Convenient formal synthesis of (±)-paroxetine

A formal total synthesis of antidepressant (±)-paroxetine employing a solvent-free Heck reaction is disclosed. Copyright Taylor & Francis Group, LLC.

An approach to the tricyclic core of madangamines based upon a biogenetic scheme

(Chemical Equation Presented) A short synthesis of intermediates possessing the tricyclic core of natural madangamines, bioactive alkaloids found in marine sponges, is described. The key reaction entails the condensation of the sodium salt of diethylaceto