88991-32-6

Basic information

• Product Name: 2-Propenoic acid, 2-(benzoylamino)-3-(2-thienyl)-, methyl ester, (2Z)-
• CAS NO: 88991-32-6
• Molecular Formula: C15H13NO3S
• Molecular Weight: 287.339
• Mol File: 88991-32-6.mol

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-(benzoylamino)-3-(2-thienyl)-, methyl ester, (2Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-(benzoylamino)-3-(2-thienyl)-, methyl ester, (2Z)-(88991-32-6)
• EPA Substance Registry System: 2-Propenoic acid, 2-(benzoylamino)-3-(2-thienyl)-, methyl ester, (2Z)-(88991-32-6)

Safety Data

• Hazardous Substances Data: 88991-32-6(Hazardous Substances Data)

Upstream product

• 495-69-2 Hippuric Acid 
• 98-03-3 thiophene-2-carbaldehyde 
• 67-56-1 methanol 
• 68100-05-0 (Z)-2-phenyl-4-(thiophen-2-ylmethylene)oxazol-5(4H)-one 

Downstream Products

• 113505-88-7 cis-3-benzamido-3-carbomethoxy-4-(2-thienyl)-Δ¹-pyrazoline 

Relevant articles and documents

UNUSUAL AMINO ACIDS. IV. ASYMMETRIC SYNTHESIS OF THIENYLALANINES

(Z)-2-N-Acylamino-3-thienyl-acrylic acids and thei esters were prepared by known procedures and hydrogenated to the corresponding optically active 2-N-acetyl(or benzoyl)-3-(2- or 3-thienyl)-alanines with optically yields up to 90percent using the rhodium complexes of 'PROPRAPHOS" 6a,b and O,N-bis(diphenylphosphino)-2-exo-hydroxy,3-endo-methylamino-norbornane 6c as chiral catalysts.Recrystallization and deacylation of the obtained amino acid derivatives yields the optically pure hydrochlorides of the thienylalanines as the free amino acids.

On the Synthesis of 3(5)-Carbomethoxy-4-hetarylpyrazoles

3(5)-Carbomethoxy-4-hetarylpyrazoles 3 can be obtained by the aromatization of the corresponding cis-3-benzamido-3-carbomethoxy-4-hetaryl-Δ1-pyrazolines 2 obtained by 1,3-dipolar cycloaddition of diazomethane with methyl Z-2-benzamido-3-hetarylpropenoates 1.An explanation, based on FMO theory, for the different reactivity of the dipolarophiles with diazomethane is given.