891005-02-0Relevant articles and documents
Acetyl nitrate mediated conversion of methyl ketones to diverse carboxylic acid derivatives
Bernard, Josephine,Capilato, Joseph N.,Hoy, Erik P.,Mattiucci, Joseph,Pellegrinelli, Peter J.,Perez, Lark J.,Philippi, Shane,Schnorbus, Logan
, p. 5298 - 5302 (2021/06/30)
The development of a novel acetyl nitrate mediated oxidative conversion of methyl ketones to carboxylic acid derivatives is described. By analogy to the haloform reaction and supported by experimental and computational investigation we propose a mechanism for this transformation.
Synthesis method of Tafamidis and derivative thereof
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Paragraph 0068-0070, (2021/08/21)
The invention provides a synthesis method for preparing Tafamidis and a derivative thereof from 6-amino-m-cresol and an aldehyde compound under the action of sodium periodate and potassium permanganate. In the method, the use of an acylation reagent dichlorobenzoyl chloride and an esterification reagent (trimethylsilyl) diazomethane is avoided, and the problem that acyl chloride, a diazonium reagent, a strong acid and strong alkali additive and the like are harmful to the environment is solved; the reaction steps are few, and the total yield is high; methoxy, halogen, trifluoromethyl and the like can be well tolerated; and the iodate and the manganese dioxide after the reaction are insoluble in the reaction solution and can be well recycled, so that the pollution caused by the reaction system is greatly reduced, a more economical and environment-friendly path is provided for synthesis of Tafamidis and the derivative thereof, and the method has a huge application value.
Magnetically recoverable and reusable CuFe2O4 nanoparticle-catalyzed synthesis of benzoxazoles, benzothiazoles and benzimidazoles using dioxygen as oxidant
Yang, Daoshan,Zhu, Xiao,Wei, Wei,Sun, Nana,Yuan, Li,Jiang, Min,You, Jinmao,Wang, Hua
, p. 17832 - 17839 (2014/05/06)
A green and efficient strategy for the synthesis of benzoxazoles, benzothiazoles and benzimidazoles has been developed by using inexpensive, readily available, dioxygen-stable and recyclable CuFe2O4 as the nanocatalyst, and o-substituted aminobenzene and various aldehydes as the starting materials. The CuFe2O4 nanoparticles are dioxygen insensitive and easily recoverable with an external magnet from the reaction medium. The catalyst can be reused ten times without significant loss of catalytic activity. This journal is the Partner Organisations 2014.
Efficient indirect electrochemical synthesis of 2-substituted benzoxazoles using sodium iodide as mediator
Li, Wei-Cui,Zeng, Cheng-Chu,Hu, Li-Ming,Tian, Hong-Yu,Little, R. Daniel
, p. 2884 - 2890 (2014/03/21)
An electrochemical strategy for the effi-cient synthesis of 2-substituted benzoxazoles was de-veloped using a catalytic amount of sodium iodide (Nal) as a redox catalyst in a two-phase buffer system.
Synthesis of benzoxazoles by the copper triflate catalysed reaction of nitriles and o-aminophenols
Tan, Heng,Pan, Cheng-Xue,Xu, Yan-Li,Wang, Heng-Shan,Pan, Ying-Ming
experimental part, p. 370 - 373 (2012/09/21)
An efficient procedure for the synthesis of benzoxazoles by the heteroannulation of nitriles and o-aminophenols in the presence of a catalytic amount of copper(II) trifluoromethanesulfonate, has been developed. This method represents a practical and attractive alternative for the synthesis of both 2-arylbenzoxazoles and 2-alkylbenzoxazoles.