89198-46-9

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 121-45-9 phosphorous acid trimethyl ester 

Downstream Products

• 141543-14-8 [1-(4-Fluoro-phenyl)-1-hydroxy-2-nitro-ethyl]-phosphonic acid dimethyl ester 
• 1049009-07-5 ethyl (E)-3-(dimethoxyphosphinyl)-3-(4-fluorophenyl)-2-propenoate 
• 1174511-33-1 (cyano)(diethoxyphosphoryl)(4-fluorophenyl)methyl dimethyl phosphate 
• 1599441-49-2 1-(dimethylphosphono)-2-oxo-1,2-bis(4-fluorophenyl)ethyl dimethyl phosphate 
• 1402349-90-9 C₁₃H₁₉FNO₄PSi 
• 183240-18-8 (+/-)-dimethyl hydroxy(4-fluorophenyl)methylphosphonate 
• 1307916-30-8 dimethyl 1-(4-fluorophenyl)-1-hydroxypropylphosphonate 
• 401610-05-7 dimethyl α-hydroxy-α-methyl-4-fluorobenzylphosphonate 
• 1307915-99-6 dimethyl (4-fluorophenyl)bis(1-methyl-1H-indol-3-yl)methylphosphonate 

Relevant academic research and scientific papers

One-pot synthesis of phosphinylphosphonate derivatives and their anti-tumor evaluations

This paper reports on the synthesis of new hydroxymethylene-(phosphinyl)phosphonates (HMPPs). A methodology has been developed to propose an optimized one-pot procedure without any intermediate purifications. Various aliphatic and (hetero)aromatic HMPPs were synthesized in good to excellent yields (53–98%) and the influence of electron withdrawing/donating group substitution on aromatic substrates was studied. In addition, the one-pot synthesis of HMPP was monitored by31P NMR spectroscopy, allowing effective control of the end of the reaction and identification of all phosphorylated intermediate species, which enabled us to propose a reaction mechanism. Optimized experimental conditions were applied to the preparation of biological relevant aminoalkyl-HMPPs. A preliminary study of the complexation to hydroxyapatite (bone matrix) was carried out in order to verify its lower affinity towards bone compared to bisphosphonate molecules. Moreover, in vitro anti-tumor activity study revealed encouraging antiproliferative activities on three human cancer cell lines (breast, pancreas and lung).

Reactions of acyl phosphonates with organoaluminum reagents: A new method for the synthesis of secondary and tertiary α-hydroxy phosphonates

The reactions of organoaluminum reagents (trimethylaluminum, triethylaluminum, etc.) with aryl and alkyl acyl phosphonates, which lead to the formation of α-hydroxy phosphonates in moderate to good yields, are reported. This method provides easy access to

gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity

New diphosphonate compounds and related derivatives were synthesized and investigated for their activity in specifically inducing plasma high density lipoproteins (HDL) and high density lipoprotein cholesterol (HDL-C) in normal rats. The screening of nume