89228-42-2

Usage

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 4939, 1983 DOI: 10.1016/S0040-4039(01)99816-8

Upstream product

• 67-56-1 methanol 
• 91586-32-2 5,6,7,8-tetrahydro-1-hydroxy-3-naphthoic acid 
• 872-36-6 vinylene carbonate 
• 85531-80-2 methyl 2-oxo-2,5,6,7,8-pentahydro-2H-benzo[b]pyran-3-ylcarboxylate 
• 108-94-1 cyclohexanone 
• 34205-71-5 methyl 4-hydroxy-2-naphthalenecarboxylate 

Downstream Products

• 529-35-1 5,6,7,8-Tetrahydronaphthalen-1-ol 

Relevant academic research and scientific papers

INDOLE MACROCYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE

The present invention relates to an indole macrocyclic derivative, a preparation method therefor and an application thereof in medicine. Specifically, the present invention relates to an indole macrocyclic derivative represented by general formula (IM), a preparation method therefor, a pharmaceutical composition containing the derivative, and a use thereof as a therapeutic agent, especially as an MCL-1 inhibitor. Each substituent of general formula (IM) is the same as those defined in the description.

Inverse Electron Demand Diels-Alder Reactions of 3-Carbomethoxy-2-pyrones. Controlled Introduction of Oxygenated Aromatics: Benzene, Phenol, Catechol, Resorcinol, and Pyrogallol Annulation. Regiospecific Total Synthesis of Sendaverine and a Preparation of 6,7-Benzomorphans

A full investigation of the preparation and Diels-Alder reactions of 3-carbomethoxy-2-pyrones is described.Methods for the preparation of a full range of oxygen-substituted aromatics: benzene, 1-, 2-, or 3-phenol, symmetrical or unsymmetrical o-catechol, resorcinol, and pyrogallol annulation from a common 3-carbomethoxy-2-pyrone intermediate are detailed.A regiospecific total synthesis of sendaverine, a 2-benzyltetrahydroisoquinoline possessing a selectively protected, symmetrical o-catechol, and a preparation of 6,7-benzomorphans are described.

INVERSE ELECTRON DEMAND DIELS-ALDER REACTIONS OF 3-CARBOMETHOXY-2-PYRONES. CONTROLLED INTRODUCTION OF OXYGENATED AROMATICS: BENZENE, PHENOL, CATECHOL, RESORCINOL, PYROGALLOL ANNULATION.

Implementation of one of four inverse electron demand Diels-Alder reactions of 3-carbomethoxy-2-pyrones with N-vinyl-2-pyrrolidinone, vinylene carbonate, 1,1-dimethoxy-ethylene or 1,1,2-trimethoxyethylene followed by choice of two standard reaction sequences: (1) removal of the carbomethoxy group (NaOH: copper powder, quinoline , Δ) or (2) its conversion to an acetate allows the preparation of a full range of oxygen substituted aromatics from a single intermediate and represent methods of benzene, 1-, 2- or 3-phenol , symmetrical or unsymmetrical catechol, resorcinol and pyrogallol annulation.