892387-01-8

Upstream product

• 52450-18-7 3'-amino-3'-deoxythymidine 
• 892386-99-1 carbonic acid 1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-nitro-phenyl}-ethyl ester 2,5-dioxo-pyrrolidin-1-yl ester 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 

Relevant academic research and scientific papers

Four-color, enzyme-free interrogation of DNA sequences with chemically activated, 3′-fluorophore-labeled nucleotides

(Figure Presented) Color reveals base: The enzymatic template-directed elongation of primers with fluorophore-labeled nucleoside triphosphates is the most frequently used reaction for determining DNA sequences. Primer extension followed by optical read out can now be achieved without enzymes.

POLYMERASE-INDEPENDENT ANALYSIS OF THE SEQUENCE OF POLYNUCLEOTIDES

The present invention concerns methods of polymerase independent template directed elongation of polynucleotides, nucleotide building blocks used in these methods as well as the use of the methods and building blocks for the determination of nucleotide sequences, in particular for the determination of SNPs, base modifications, mutations, rearrangements and methylation patterns.