892869-48-6

Basic information

• Product Name: 2-Hydroxyethyl oleanolate
• Synonyms: 2-Hydroxyethyl oleanolate;(3β)-3-Hydroxy-olean-12-en-28-oic acid 2-hydroxyethyl ester;2-Hydroxyethyl (3beta)-3-hydroxyolean-12-en-28-oate;(3beta)-3-Hydroxy-olean-12-en-28-oic acid 2-hydroxyethyl ester
• CAS NO: 892869-48-6
• Molecular Formula: C32H52O4
• Molecular Weight: 500.75
• Product Categories: Pentacyclic triterpenes
• Mol File: 892869-48-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Hydroxyethyl oleanolate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxyethyl oleanolate(892869-48-6)
• EPA Substance Registry System: 2-Hydroxyethyl oleanolate(892869-48-6)

Safety Data

• Hazardous Substances Data: 892869-48-6(Hazardous Substances Data)

Usage

General Description

2-Hydroxyethyl oleanolate is a chemical compound derived from oleanolic acid, a naturally occurring triterpenoid found in many plants. It is formed by the addition of a hydroxyl group and an ethyl group to the oleanolate molecule. It has been studied for its potential as an anti-inflammatory and anti-cancer agent. 2-Hydroxyethyl oleanolate has shown promising results in inhibiting the growth of cancer cells and reducing inflammation in experimental studies. It also has potential as a skincare ingredient due to its moisturizing and anti-inflammatory properties. However, further research is needed to fully understand its biological effects and potential applications.

Upstream product

• 508-02-1 Oleanolic acid 
• 540-51-2 2-bromoethanol 
• 875753-08-5 2-bromoethyl 3β-hydroxyolean-12-en-28-oate 

Relevant articles and documents

Combination of amino acid/dipeptide with nitric oxide donating oleanolic acid derivatives as PepT1 targeting antitumor prodrugs

By taking advantage of the cytotoxic effect of nitric oxide (NO) and PepT1 for molecule-targeted drug delivery, a series of amino acid/dipeptide diester prodrugs of NO-donating oleanolic acid derivatives were designed and synthesized. Two prodrugs 6a and 8a showed potent cytotoxcity, which is probably due to their high PepT1 affinity and NO-releasing ability. Furthermore, the aqueous solubility of the prodrugs was also significantly enhanced because of the hydrophilic amino acid/dipeptide promoiety.

Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase

Oleanolic acid and its synthetic derivatives have been identified as novel inhibitors of glycogen phosphorylase. Within this series of compounds, 4 (IC50 = 3.3 μM) is the most potent GPa inhibitor. Preliminary structure-activity relationships of the oleanolic acid derivatives are discussed.