89302-15-8

Basic information

• Product Name: (5-METHOXY-2-NITRO-PHENYL)-ACETONITRILE
• Synonyms: (5-METHOXY-2-NITRO-PHENYL)-ACETONITRILE;2-NITRO-5-METHOXYPHENYLACETONITRILE
• CAS NO: 89302-15-8
• Molecular Formula: C₉H₈N₂O₃
• Molecular Weight: 192.17
• Mol File: 89302-15-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 366.9 °C at 760 mmHg
• Flash Point: 175.7 °C
• Appearance: /
• Density: 1.268 g/cm³
• Vapor Pressure: 1.41E-05mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: (5-METHOXY-2-NITRO-PHENYL)-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-METHOXY-2-NITRO-PHENYL)-ACETONITRILE(89302-15-8)
• EPA Substance Registry System: (5-METHOXY-2-NITRO-PHENYL)-ACETONITRILE(89302-15-8)

Safety Data

• Hazardous Substances Data: 89302-15-8(Hazardous Substances Data)

Usage

General Description

"(5-Methoxy-2-nitro-phenyl)-acetonitrile" is a chemical compound with the molecular formula C9H8N2O3. It is a yellow crystalline solid that is commonly used in organic synthesis as a reagent and intermediate. (5-METHOXY-2-NITRO-PHENYL)-ACETONITRILE has a nitro group and a methoxy group attached to a phenyl ring, as well as a cyano group attached to the acetonitrile group. It is often used in the pharmaceutical industry for the synthesis of various drugs and active pharmaceutical ingredients. Its properties and structure make it useful for the development of new compounds with potential therapeutic effects.

InChI:InChI=1/C9H8N2O3/c1-14-8-2-3-9(11(12)13)7(6-8)4-5-10/h2-3,6H,4H2,1H3

Upstream product

• 491-11-2 3-chloro-4-nitrophenol 
• 5367-32-8 5-methoxy-2-nitrotoluene 
• 67567-46-8 2‐(bromomethyl)‐4‐methoxy‐1‐nitrobenzene 
• 100-02-7 4-nitro-phenol 
• 19924-43-7 3-methoxyphenylacetonitrile 
• 82204-34-0 (5-methoxy-2-nitro-phenyl)-pyruvic acid 
• 28987-59-9 3-chloro-4-nitroanisole 
• 40140-91-8 3-chloro-4-nitrosophenol 
• 97655-38-4 ethyl α-cyano-5-methoxy-2-nitrobenzene acetate 
• 100-17-4 para-methoxynitrobenzene 
• 3598-13-8 (4-chlorophenoxy)acetonitrile 
• 61540-35-0 S-(Dimethylthiocarbamoyl)thioglycolonitrile 

Downstream Products

• 111795-98-3 ethyl-4-cyano-4-(5-methoxy-2-nitrophenyl)butyrate 
• 138469-69-9 2-(5-methoxy-2-nitrophenyl)pent-4-enenitrile 
• 138469-73-5 2-cyclohexyl-2-(2-nitro-5-methoxyphenyl)acetonitrile 
• 20876-29-3 2-(5-methoxy-2-nitrophenyl)acetic acid 
• 180149-25-1 2-(5-methoxy-2-nitrophenyl)-ethylamine 
• 138469-72-4 2-(5-methoxy-2-nitrophenyl)pentanenitrile 
• 111795-96-1 2-(5-methoxy-2-nitrophenyl)propanenitrile 
• 1417791-46-8 C₁₇H₁₄N₂O₄ 
• 1417791-45-7 C₁₅H₁₈N₂O₄ 
• 1159007-53-0 6-[4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid-phenylamide 
• 1159006-95-7 7-methoxy-3-{1-[6-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-carbonyl)-pyrimidin-4-yl]-piperidin-4-yl}-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one 
• 1159006-91-3 6-[4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid benzyl-(2,2,2-trifluorethyl)-amide 
• 481668-37-5 5-methoxy-2-methyl-1H-indole-3-carbonitrile 
• 1310481-73-2 3-cyano-2-(1-phenylethyl)-5-methoxyindole 

Relevant articles and documents

Palladium-Catalyzed Dual Annulation: A Method for the Synthesis of Norneocryptolepine

A novel procedure for the Pd-catalyzed dual annulation reaction to synthesize the norneocryptolepine derivatives involving the concerted construction of two central heterocycles is reported. The further methylation of the norneocryptolepine to afford its alkaloid analog neocryptolepine implies that synthesis of various neocryptolepine derivatives is feasible. The oxidative addition of Pd(0) is indicated as the key step to activate the intramolecular addition of nitrile according to the mechanism study.

Active and Recyclable Catalytic Synthesis of Indoles by Reductive Cyclization of 2-(2-Nitroaryl)acetonitriles in the Presence of Co-Rh Heterobimetallic Nanoparticles with Atmospheric Hydrogen under Mild Conditions

A cobalt-rhodium heterobimetallic nanoparticle-catalyzed reductive cyclization of 2-(2-nitroaryl)acetonitriles to indoles has been achieved. The tandem reaction proceeds without any additives under the mild conditions (1 atm H2 and 25 °C). This procedure could be scaled up to the gram scale. The catalytic system is significantly stable under these reaction conditions and could be reused more than ten times without loss of catalytic activity.

CGRP ANTAGONISTS

The present invention relates to new CGRP-antagonists of general formula I wherein U, V, X, Y, R1, R2 and R3 are defined as stated hereinafter, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, their use and processes for preparing them.