893403-87-7Relevant academic research and scientific papers
NITRIC OXIDE DONOR NEPRILYSIN INHIBITORS
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Paragraph 0428, (2014/01/07)
In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, R7, R8, Z, X, b, and c are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are nitric oxide donors and have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
NO-donor phenols: A new class of products endowed with antioxidant and vasodilator properties
Boschi, Donatella,Tron, Gian Cesare,Lazzarato, Loretta,Chegaev, Konstantin,Cena, Clara,Di Stilo, Antonella,Giorgis, Marta,Bertinaria, Massimo,Fruttero, Roberta,Gasco, Alberto
, p. 2886 - 2897 (2007/10/03)
The synthesis and study of the antioxidant and vasodilator properties of a new class of phenols able to release nitric oxide are described. The products were designed through a symbiotic approach using selected phenols and selected nitrooxy and furoxan NO
Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants
Cena, Clara,Boschi, Donatella,Tron, Gian Cesare,Chegaev, Kostantin,Lazzarato, Loretta,Stilo, Antonella Di,Aragno, Manuela,Fruttero, Roberta,Gasco, Alberto
, p. 5971 - 5974 (2007/10/03)
A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lip
