58265-36-4

Basic information

• Product Name: 2-methyl-N,2-diphenylpropanamide
• CAS NO: 58265-36-4
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.3123
• Mol File: 58265-36-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 426.1°C at 760 mmHg
• Flash Point: 258.1°C
• Density: 1.102g/cm³
• Vapor Pressure: 1.82E-07mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 2-methyl-N,2-diphenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-N,2-diphenylpropanamide(58265-36-4)
• EPA Substance Registry System: 2-methyl-N,2-diphenylpropanamide(58265-36-4)

Safety Data

• Hazardous Substances Data: 58265-36-4(Hazardous Substances Data)

Upstream product

• 89372-28-1 1-(2-methyl-2-phenylpropanoyl)-1H-imidazole 
• 62-53-3 aniline 
• 1678-25-7 N-phenylbenzenesulfonamide 
• 2173-69-5 2-methyl-2-phenyl-propan-1-ol 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 2901-13-5 ethyl 2-methyl-2-phenylpropionate 
• 98-95-3 nitrobenzene 
• 36293-05-7 2-methyl-2-phenylpropanoyl chloride 
• 98-86-2 acetophenone 
• 201230-82-2 carbon monoxide 
• 98-83-9 isopropenylbenzene 
• 142-04-1 aniline hydrochloride 
• 52412-43-8 5,5-dimethyl-3,4-diphenyl-4,5-dihydro-3H-[1,2,3]triazol-4-ol 
• 5682-41-7 2,3-diphenyl-2-methylpropan-3-one oxime 

Relevant articles and documents

Palladium-Catalyzed Markovnikov Hydroaminocarbonylation of 1,1-Disubstituted and 1,1,2-Trisubstituted Alkenes for Formation of Amides with Quaternary Carbon

Hydroaminocarbonylation of alkenes is one of the most promising yet challenging methods for the synthesis of amides. Herein, we reported the development of a novel and effective Pd-catalyzed Markovnikov hydroaminocarbonylation of 1,1-disubstituted or 1,1,2-trisubstituted alkenes with aniline hydrochloride salts to afford amides bearing an α quaternary carbon. The reaction makes use of readily available starting materials, tolerates a wide range of functional groups, and provides a facile and straightforward approach to a diverse array of amides bearing an α quaternary carbon. Mechanistic investigations suggested that the reaction proceeded through a palladium hydride pathway. The hydropalladation and CO insertion are reversible, and the aminolysis is probably the rate-limiting step.

Chromium-Catalyzed Activation of Acyl C-O Bonds with Magnesium for Amidation of Esters with Nitroarenes

Here, we report a chromium-catalyzed activation of acyl C-O bonds with magnesium for amidation of esters with nitroarenes. Low-cost chromium(III) chloride shows high reactivity in promoting amidation by using magnesium as reductant and chlorotrimethylsilane as additive. It provides a step-economic strategy to the synthesis of centrally important amide motifs using inexpensive and air-stable nitroarenes as amino sources.

Rhodium-Catalyzed oxidative amidation of sterically hindered aldehydes and alcohols

A rhodium-catalyzed oxidative amidation reaction has been developed with sterically hindered aldehydes and alcohols for the synthesis of amides containing a quaternary carbon at the α position. A variety of amine nucleophiles, both aliphatic and aromatic, are employed and afford the corresponding amides in good to excellent yields. Finally, mechanistic studies are performed to gain insight into both catalytic cycles.